Gerald S. Shadel

Salk Institute for Biological Studies — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

76h-index24.1kcitations194works21.12yr avg
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Research Topics

Mitochondrial Function and Pathology(95), interferon and immune responses(30), RNA modifications and cancer(26), ATP Synthase and ATPases Research(26), RNA Research and Splicing(21)

Publications194 total

Kidney mitochondrial DNA contributes to systemic IL-6 release in sepsis-associated acute kidney injury
JCI Insight·2025Open Access
Retraction Notice to “Aberrant CD8+ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling” [Am J Pathol 178 (2011) 2740–2751]
American Journal Of Pathology·2025Open Access
ROS-dependent localization of glycolytic enzymes to mitochondria
Redox Biology·2025· 1 citedOpen Access
Multi-site phosphorylation of BCL2L13 in a TBK1- and AMPK-dependent manner reveals new modes of mitophagy regulation
2025· 2 citedOpen Access
FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion
The Journal of Cell Biology·2025· 5 citedOpen Access
Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
Science·2025· 97 citedOpen Access
Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer
2024Open Access
Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and metabolic inflexibility
Free Radical Biology and Medicine·2024
INF2-mediated actin polymerization at ER-organelle contacts regulates organelle sizeand movement
2024· 2 citedOpen Access
Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer
2024· 3 citedOpen Access
INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement
2024· 4 citedOpen Access
Protocol for the San Diego Nathan Shock Center Clinical Cohort: a new resource for studies of human aging
BMJ Open·2024· 2 citedOpen Access
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
Cell·2024· 88 citedOpen Access
Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal
Nature Cell Biology·2024· 103 citedOpen Access
Author Correction: Apoptotic stress causes mtDNA release during senescence and drives the SASP
Nature·2024· 11 citedOpen Access
Apoptotic stress causes mtDNA release during senescence and drives the SASP
Nature·2023· 510 citedOpen Access
Manipulating mitochondrial electron flow enhances tumor immunogenicity
Science·2023· 105 citedOpen Access
Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
Cell·2023· 224 citedOpen Access
Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
Human Molecular Genetics·2023· 27 citedOpen Access
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
Science·2023· 173 citedOpen Access
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Frequent Co-authors

A. Phillip West(7), Nuno Raimundo(4), Akiko Iwasaki(4), David A. Clayton(4), Nicholas D. Bonawitz(4), Yong Pan(4), Dong Kyun Woo(3), Marcus Bosenberg(3), Elizabeth A. Schroeder(3), Timothy E. Shutt(3), Laura Newman(3), Jana S. Eaton(3), Vicki McCulloch(3), Michal Caspi Tal(2), Sabine M. Lang(2), Susan M. Kaech(2), Sankar Ghosh(2), Brian Yordy(2), Valter D. Longo(2), Brian K. Kennedy(2)