Sharrol Bachas

Onai (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index299citations21works8.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(5), Drug Transport and Resistance Mechanisms(5), Monoclonal and Polyclonal Antibodies Research(5), RNA and protein synthesis mechanisms(4), Bacterial Genetics and Biotechnology(3)

Publications21 total

Iterative Epitope Expansion Enables Structure-Guided <i>de novo</i> Design of IgE-Binding Miniproteins Targeting the Fc <i>ε</i> RI Interface
2025
AIntibody: an experimentally validated in silico antibody discovery design challenge
Nature Biotechnology·2024· 16 citedOpen Access
IgDesign: <i>In vitro</i> validated antibody design against multiple therapeutic antigens using inverse folding
2023· 22 citedOpen Access
Unlocking <i>de novo</i> antibody design with generative artificial intelligence
2023· 77 citedOpen Access
Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness
2022· 65 citedOpen Access
Convergent Use of Heptacoordination for Cation Selectivity by RNA and Protein Metalloregulators
Cell chemical biology·2018· 30 citedOpen Access
Crystal structure of the L.Lactis YkoY riboswitch bound to cadmium
2018· 1 cited
Induced fit in the specific recognition of transition metal ions by a gene-regulatory RNA
Acta Crystallographica Section A Foundations and Advances·2017Open Access
Back Cover: Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR (ChemMedChem 6/2017)
ChemMedChem·2017
Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR
ChemMedChem·2017· 2 cited
Solution Binding and Structural Analyses Reveal Potential Multidrug Resistance Functions for SAV2435 and CTR107 and Other GyrI-like Proteins
Biochemistry·2016· 14 cited
Cover Picture: Charge is Major Determinant of Activation of the Ligand‐Responsive Multidrug Resistance Gene Regulator, BmrR (ChemMedChem 10/2016)
ChemMedChem·2016
Charge is Major Determinant of Activation of the Ligand‐Responsive Multidrug Resistance Gene Regulator, BmrR
ChemMedChem·2016· 5 cited
Allosteric Coupling via Distant Disorder-to-Order Transitions
Journal of Molecular Biology·2015· 28 cited
Multidrug recognition and Multidrug transcription activation by the gene regulator, BmrR
2014
Allosteric Coupling via Communication of Distal Disorder-To-Order Transitions
Biophysical Journal·2014Open Access
Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR
Proceedings of the National Academy of Sciences·2011· 39 cited
Crystal structure of BmrR bound to Tetracycline
2010
Crystal structure of BmrR bound to puromycin
2010
Crystal Structure of BmrR bound to ethidium
2010
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Frequent Co-authors

Herschel Wade(12), Christopher Eginton(7), Bryan Kohrs(4), G. Gunio(4), George W. Kasun(3), John M. Sutton(3), Cailen M. McCloskey(3), S. G. LEVINE(3), Christa Kohnert(3), Rebecca Consbruck(3), Hayley Carter(3), Shaheed Abdulhaqq(3), Joshua Meier(3), A.R. Ferré-D′Amaré(3), Amir Shanehsazzadeh(2), Edriss Yassine(2), Julian Alverio(2), Goran Rakočević(2), Jahir M. Gutierrez(2), Chelsea Chung(2)