Bruce A. Yankner

Medicine · Health Sciences

63h-index34.1kcitations111works45.02yr avg
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Research Topics

Alzheimer's disease research and treatments(51), Prion Diseases and Protein Misfolding(13), Genetics, Aging, and Longevity in Model Organisms(11), Cholinesterase and Neurodegenerative Diseases(11), Cellular transport and secretion(9)

Publications110 total

Lithium deficiency and the onset of Alzheimer’s disease
Nature·2025· 45 citedOpen Access
Impaired neural stress resistance and loss of REST in bipolar disorder
Molecular Psychiatry·2023· 7 citedOpen Access
A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer’s disease
Nature Communications·2023· 13 citedOpen Access
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder
Nature Communications·2022· 22 citedOpen Access
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression
Science Advances·2022· 43 citedOpen Access
Neuronal Excitatory State Is Linked to Stress Resilience
Innovation in Aging·2021Open Access
The adaptive aging brain
Current Opinion in Neurobiology·2021· 67 citedOpen Access
REST and Stress Resistance in the Aging Kidney
Journal of the American Society of Nephrology·2021· 10 citedOpen Access
Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel <i>in situ</i> analyses
Nucleic Acids Research·2021· 63 citedOpen Access
Data integration of bulk and single-cell transcriptomics from cerebral organoids and post-mortem brains to identify cell types and cell type specific driver genes in autism
2020Open Access
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids
2020· 5 citedOpen Access
Regulation of lifespan by neural excitation and REST
Nature·2019· 238 cited
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease
Cell Reports·2019· 221 citedOpen Access
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Cell·2018· 445 citedOpen Access
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
Neuron·2018· 208 citedOpen Access
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
Neuron·2018· 1.1k citedOpen Access
Barcoded oligonucleotides ligated on RNA amplified for multiplex and parallel in-situ analyses
2018· 12 citedOpen Access
Slowing Down Aging
Cell Metabolism·2017· 13 citedOpen Access
神経の同調を回復させてアルツハイマー病を治療
Nature Digest·2017
Neural synchronization in Alzheimer's disease
Nature·2016· 47 citedOpen Access
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Frequent Co-authors

Tao Lu(11), Alfredo Lorenzo(7), Jorge Busciglio(7), Junying Yuan(6), Menglan Yuan(5), Ying Pan(4), Liviu Aron(4), Dana Gabuzda(4), Zhuohua Zhang(4), Jin Xu(3), Lawrence K. Duffy(3), Jinsoo Seo(3), Heather Feldman(3), Li‐Huei Tsai(3), Patrick Loerch(3), Derek Drake(3), Weihong Song(3), Hong Zhu(2), Shyan-Yuan Kao(2), Nicholas A. Bishop(2)