Kang Hu

Medicine · Health Sciences

12h-index10.3kcitations18works0.02yr avg
OpenAlex↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Alzheimer's disease research and treatments(14), Computational Drug Discovery Methods(7), Cholinesterase and Neurodegenerative Diseases(7), Drug Transport and Resistance Mechanisms(5), Neuroscience and Neuropharmacology Research(3)

Publications18 total

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Journal of Medicinal Chemistry·2013· 32 cited
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
Alzheimer s Research & Therapy·2010· 50 citedOpen Access
P3‐320: Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP‐selective gamma‐secretase inhibitor, on amyloid‐β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration
Alzheimer s & Dementia·2010· 12 cited
P1‐035: Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a non‐transgenicA‐beta mouse efficacy model
Alzheimer s & Dementia·2009Open Access
P4‐019: Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a nontransgenic A‐beta mouse efficacy model
Alzheimer s & Dementia·2009· 1 cited
Identification of -Secretase Inhibitor Potency Determinants
2008
Identification of γ-Secretase Inhibitor Potency Determinants on Presenilin
Journal of Biological Chemistry·2007· 61 citedOpen Access
Aβ42 immunization in Alzheimer's disease generates Aβ N-terminal antibodies
Annals of Neurology·2005· 129 cited
P4-401 Characterization of the humoral response to AN1792 immunization in AD patients
Neurobiology of Aging·2004· 1 cited
P4-183 Molecular determinants of substrate recognition by the Alzheimer amyloid peptide generating protease, β-secretase (BACE)
Neurobiology of Aging·2004
Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer's disease-like neuropathology
Proceedings of the National Academy of Sciences·2003· 391 citedOpen Access
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Journal of Neurochemistry·2001· 877 citedOpen Access
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
Nature Medicine·2000· 2.0k citedOpen Access
High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
Journal of Neuroscience·2000· 1.9k citedOpen Access
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
The Society for Neuroscience Abstracts·2000· 3 cited
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Nature·1999· 3.1k cited
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Proceedings of the National Academy of Sciences·1999· 1.1k citedOpen Access
Amyloid precursor protein processing and Aβ <sub>42</sub> deposition in a transgenic mouse model of Alzheimer disease
Proceedings of the National Academy of Sciences·1997· 655 citedOpen Access

Frequent Co-authors

Dora Kholodenko(10), Dale Schenk(9), Ruth Motter(9), Kelly Johnson‐Wood(8), Mike Lee(8), Guriqbal S. Basi(8), Erich Goldbach(7), Ted Yednock(6), Peter Seubert(6), Robin Barbour(5), Ivan Lieberburg(5), Ferdie Soriano(5), Frédérique Bard(5), Jacek Jagodziński(5), Elizabeth Brigham(5), Daniel Ness(5), Karen Khan(4), Linda Mutter(4), Dora Games(4), Lisa McConlogue(4)