John D. Crispino

St. Jude Children's Research Hospital — United States

Medicine · Health Sciences

66h-index13.5kcitations372works1.02yr avg
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Research Topics

Acute Myeloid Leukemia Research(156), Myeloproliferative Neoplasms: Diagnosis and Treatment(95), Chronic Myeloid Leukemia Treatments(72), Acute Lymphoblastic Leukemia research(50), Chronic Lymphocytic Leukemia Research(47)

Publications372 total

Inhibition of the EBF1-ITGB8 Axis in Bone Marrow Niche Ameliorates Hallmarks of Myelofibrosis
2026Open Access
Loss of cystathionine-β-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome
Biochemical Pharmacology·2026
GATA1 N-terminus coordinates metabolic reprogramming in erythropoiesis
Blood·2026Open Access
FBXO11 suppression rewires an NPM1-centered interactome influencing the progression of myelodysplastic syndrome
Journal of Clinical Investigation·2026Open Access
Assessing the contributions of noncoding RNAs in acute myeloid leukemia
Blood Neoplasia·2026Open Access
Single-cell transcriptomic studies reveal altered heterogeneity in CD41 enriched megakaryocytes after targeted therapy in myeloproliferative neoplasm
Blood·2025
Menin inhibition as a new therapeutic option for the myeloproliferative neoplasms
Blood·2025
Aberrant thymic architecture and enhanced interferon signaling in down syndrome
Blood·2025Open Access
Megakaryocytes engage in emperipolesis with neutrophils and emperipolesis by the immune MK subset leads to efferocytosis and is exacerbated by CXCR1/2 activation in myelofibrosis
Blood·2025
1020 – TARGETING THE EBF1-ITGB8 AXIS IN THE BONE MARROW NICHE AS A PROMISING THERAPEUTIC APPROACH FOR MYELOFIBROSIS
Experimental Hematology·2025
RPS19 and RPL5 Haploinsufficient Models Reveal Divergent Ribosomal Subunit Controls of Fetal Hematopoiesis
2025Open Access
Meddling with METTL3 in acute megakaryoblastic leukemia
Blood·2025Open Access
Loss of Function Mouse Models Reveal a Novel Regulatory Function for ULK1 in Myeloproliferative Neoplasms
Molecular and Cellular Biology·2025
Corrigendum to STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice
Journal of Clinical Investigation·2025Open Access
Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
Nature Genetics·2025· 4 citedOpen Access
Splicing of erythroid transcription factor is associated with therapeutic response in myelodysplastic syndromes
Journal of Clinical Investigation·2025· 2 citedOpen Access
Generating Off‐the‐Shelf Hematopoietic Stem Cells by “Stretching” Induced Pluripotent Stem Cells
American Journal of Hematology·2025· 1 citedOpen Access
DYRK1A inhibition results in MYC and ERK activation rendering KMT2A-R acute lymphoblastic leukemia cells sensitive to BCL2 inhibition
Leukemia·2025· 2 citedOpen Access
Modeling GATA2 deficiency in mice: the R396Q mutation disrupts normal hematopoiesis
Leukemia·2025· 3 citedOpen Access
Hematopoietic Stem Cell Function and Differentiation Is Regulated By DCAF7 through Polycomb Repressive Complex 1 (PRC1) Modulation
Blood·2024Open Access
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Frequent Co-authors

Sébastien Malinge(8), Stuart H. Orkin(7), Sandeep Gurbuxani(7), Michelle M. Le Beau(4), Mitchell J. Weiss(4), Zan Huang(4), Jeffrey W. Taub(4), Joshua B. Wechsler(3), Marianne E. Greene(3), D. Gary Gilliland(3), Mortimer Poncz(3), Benjamin Goldenson(3), Thomas Mercher(3), Maya Lodish(3), Lauren Diebold(3), Louis C. Doré(3), Shai Izraeli(3), Gina Mundschau(3), Alan S. Gamis(3), Gina Kirsammer(3)