Kevin E. Knockenhauer

Accent Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.9kcitations76works0.52yr avg
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Research Topics

RNA Research and Splicing(22), Science, Research, and Medicine(20), RNA and protein synthesis mechanisms(17), Biotechnology and Related Fields(13), Steroid Chemistry and Biochemistry(12)

Publications76 total

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9
Journal of Medicinal Chemistry·2025· 6 citedOpen Access
Abstract 1758: ATX-559, a first in class DHX9 inhibitor, and targeted therapeutic for molecularly defined tumors with genomic instability and replicative stress
Cancer Research·2025· 1 cited
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor
Communications Biology·2025Open Access
Supplementary Data Figure 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Table 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 4 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Table 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Table 1 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 5 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 6 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 7 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 6 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 7 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Table 2 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 5 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
Supplementary Data Figure 3 from A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
2025Open Access
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Frequent Co-authors

Thomas Schwartz(20), Robert A. Copeland(17), P. Ann Boriack‐Sjodin(16), Deepali Gotur(15), Julie Liu(15), E. Allen Sickmier(15), Kenneth W. Duncan(15), Jennifer Castro(14), Matthew H. Daniels(14), Young‐Tae Lee(14), Shane M. Buker(14), Shihua Yao(14), Brian A. Sparling(14), April Case(13), Serena J. Silver(13), Stephen J. Blakemore(13), Scott Ribich(13), David Brennan(12), Jie Wu(12), Sunaina Nayak(12)