Jacqueline E. Testa

Proteogenomics Research Institute for Systems Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index2.6kcitations30works0.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(9), Cell Adhesion Molecules Research(6), Monoclonal and Polyclonal Antibodies Research(6), Glycosylation and Glycoproteins Research(5), Blood Coagulation and Thrombosis Mechanisms(5)

Publications30 total

In vivo proteomic imaging analysis of caveolae reveals pumping system to penetrate solid tumors
Nature Medicine·2014· 83 cited
Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo
American Journal of Physiology-Lung Cellular and Molecular Physiology·2009· 22 citedOpen Access
Ubiquitous yet Distinct Expression of Podocalyxin on Vascular Surfaces in Normal and Tumor Tissues in the Rat
Journal of Vascular Research·2009· 17 citedOpen Access
Proteomic Imaging of Endothelium and Caveolae for Targeted Penetration into Single Organs and Solid Tumors
Journal of Proteomics & Bioinformatics·2008
Erratum: Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
Nature Biotechnology·2007· 4 citedOpen Access
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
Nature Biotechnology·2007· 301 citedOpen Access
Screening phage display libraries for organ-specific vascular immunotargeting <i>in vivo</i>
Proceedings of the National Academy of Sciences·2005· 103 citedOpen Access
Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture
Nature Biotechnology·2004· 419 cited
Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
Nature·2004· 480 cited
Targeting the proteome/epitome, implementation of subtractive immunization
Biochemical and Biophysical Research Communications·2003· 27 cited
Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen
Oncogene·2003· 128 cited
Diminished expression of NF2 in metastatic malignant melanoma
Journal of Investigative Dermatology·2002
Co-inoculation of human and murine carcinoma cells induces reciprocal suppression of metastasis by both cell lines
Clinical & Experimental Metastasis·1999· 1 cited
Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis.
PubMed·1999· 156 cited
Podokinesis in endothelial cell migration: role of nitric oxide
American Journal of Physiology-Cell Physiology·1998· 184 cited
158 Chicken plasminogen activator (chuPA): Autoactivating and serpin resistant: A protease out of control
Fibrinolysis & proteolysis/Fibrinolysis and proteolysis·1997
Introduction of an RRHR motif into chicken urokinase-type plasminogen activator (ch-uPA) confers sensitivity to plasminogen activator inhibitor (PAI)-1 and PAI-2 and allows ch-uPA-mediated extracellular matrix degradation to be controlled by PAI-1
Proceedings of the National Academy of Sciences·1997· 19 citedOpen Access
Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers
Infection and Immunity·1995· 205 citedOpen Access
Avian urokinase-type plasminogen activator (u-PA) lacks the putative binding site for plasminogen activator inhibitor (PAI) and is resistant to inhibition by human PAI-1 and PAI-2
Fibrinolysis and Proteolysis·1995· 4 cited
Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.
PubMed·1992· 34 cited
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Frequent Co-authors

Jan E. Schnitzer(9), Phil Oh(8), James P. Quigley(6), Adrián Chrastina(5), J. P. Quigley(5), Per Borgström(4), Halina Witkiewicz(4), Jingyi Yu(2), Eberhard Dürr(2), Karolina Krasinska(2), Lucy A. Carver(2), Bengt Borgström(2), Koji Iwata(2), Kurt R. Zinn(2), Richard K. Baldwin(2), Andries Zijlstra(2), Arnold S. Kreger(2), Robert L. Medcalf(2), Jean‐François Cajot(2), W D Schleuning(2)