Chou-Long Huang

University of Iowa — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

51h-index7.9kcitations91works0.02yr avg
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Research Topics

Ion Transport and Channel Regulation(49), Ion channel regulation and function(37), Magnesium in Health and Disease(25), Parathyroid Disorders and Treatments(13), Ion Channels and Receptors(10)

Publications91 total

Gain-of-Function WNK4 Rescues Cell Cycle and Proliferation Defects in ClC-Kb-Deficient Thick Ascending Limb
Journal of the American Society of Nephrology·2025
WNK1 as an Osmolality Sensor: Mechanism and Structure-Function Studies
Journal of the American Society of Nephrology·2024
WNK1 regulates uterine homeostasis and its ability to support pregnancy
JCI Insight·2020· 20 citedOpen Access
WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis
Cancers·2020· 49 citedOpen Access
Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII?
Proceedings of the National Academy of Sciences·2019Open Access
WNK4 kinase is a physiological intracellular chloride sensor
Proceedings of the National Academy of Sciences·2019· 99 citedOpen Access
OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant
Proceedings of the National Academy of Sciences·2018· 37 citedOpen Access
Differential roles of WNK4 in regulation of NCC in vivo
American Journal of Physiology-Renal Physiology·2018· 25 citedOpen Access
Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
Molecular Biology of the Cell·2017· 82 citedOpen Access
Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
Proceedings of the National Academy of Sciences·2017· 89 citedOpen Access
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho
Kidney International·2016· 104 citedOpen Access
High dietary phosphate intake induces hypertension and augments exercise pressor reflex function in rats
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2016· 51 citedOpen Access
Klotho May Ameliorate Proteinuria by Targeting TRPC6 Channels in Podocytes
Journal of the American Society of Nephrology·2016· 82 citedOpen Access
Hypertension: the missing WNKs
American Journal of Physiology-Renal Physiology·2016· 24 citedOpen Access
Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis
Proceedings of the National Academy of Sciences·2016· 19 citedOpen Access
Two inwardly rectifying potassium channels,<i>Irk1</i>and<i>Irk2</i>, play redundant roles in<i>Drosophila</i>renal tubule function
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2015· 51 citedOpen Access
A unifying mechanism for WNK kinase regulation of sodium-chloride cotransporter
Pflügers Archiv - European Journal of Physiology·2015· 31 citedOpen Access
Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate
Journal of the American Society of Nephrology·2014· 260 cited
Klotho Up-regulates Renal Calcium Channel Transient Receptor Potential Vanilloid 5 (TRPV5) by Intra- and Extracellular N-glycosylation-dependent Mechanisms
Journal of Biological Chemistry·2014· 69 citedOpen Access
Novel<i>KCNJ5</i>Mutations in Sporadic Aldosterone-Producing Adenoma Reduce Kir3.4 Membrane Abundance
The Journal of Clinical Endocrinology & Metabolism·2014· 50 citedOpen Access
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Frequent Co-authors

Jian Xie(11), Seung‐Kuy Cha(8), Sung-Wan An(6), Makoto Kuro‐o(4), Shih‐Hua Lin(4), Harlan E. Ives(4), Chih‐Jen Cheng(4), Wei-Zhong Zeng(4), Donald W. Hilgemann(3), Elizabeth Kuo(3), Bernardo Ortega(3), Lutz Birnbaumer(3), Joon‐Ho Yoon(3), Melanie H. Cobb(3), Orson W. Moe(3), Tao Wu(3), Hiroshi Kurosu(2), Yuh Nung Jan(2), Lily Yeh Jan(2), Bing-e Xu(2)