Matthew J. Sale

City College of San Francisco — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.7kcitations33works5.02yr avg
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Research Topics

Melanoma and MAPK Pathways(16), Neurofibromatosis and Schwannoma Cases(7), Neuroblastoma Research and Treatments(7), Protein Kinase Regulation and GTPase Signaling(6), Cytokine Signaling Pathways and Interactions(6)

Publications33 total

EXTH-117. Bitopic inhibitors of mTORC1 cooperate with inhibitors of mitogen-activated protein kinase kinase to drive cytotoxicity in glioblastoma
Neuro-Oncology·2025Open Access
A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system
Proceedings of the National Academy of Sciences·2025Open Access
Inhibition and degradation of NRAS with a pan-NRAS monobody
Oncogene·2024· 7 citedOpen Access
Abstract 2080: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer
Cancer Research·2024
Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance
Nature Communications·2024· 18 citedOpen Access
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
Science Advances·2023· 24 citedOpen Access
The ribosomal S6 kinase 2 (RSK2)–SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling
Journal of Biological Chemistry·2023· 13 citedOpen Access
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1
Biochemical Journal·2023· 18 citedOpen Access
Abstract 1715: SOS1 inhibition is an effective therapeutic strategy in SOS1-mutant cancer
Cancer Research·2023
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization
Proceedings of the National Academy of Sciences·2023· 30 citedOpen Access
Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy
2022· 1 citedOpen Access
DDDR-06. NEUROFIBROMATOSIS TUMOR SUPPRESSORS COOPERATIVELY DRIVE TUMOR DE-DIFFERENTIATION AND MEK INHIBITOR RESISTANCE IN PERIPHERAL NERVOUS SYSTEM TUMORS
Neuro-Oncology·2022Open Access
Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistance
2022Open Access
CSIG-01. EPIGENETIC REPROGRAMMING DRIVES MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) DE-DIFFERENTIATION AND TREATMENT RESISTANCE
Neuro-Oncology·2021Open Access
Genomic Analysis and Biochemical Investigation Reveal Mechanisms of Schwann Cell Transformation and Treatment Resistance in Malignant Peripheral Nerve Sheath Tumors (MPNSTs)
International Journal of Radiation Oncology*Biology*Physics·2021Open Access
RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity
Proceedings of the National Academy of Sciences·2021· 38 citedOpen Access
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models
British Journal of Cancer·2020· 68 citedOpen Access
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
2019Open Access
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
Nature Communications·2019· 72 citedOpen Access
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance
Nature Communications·2019· 58 citedOpen Access
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Frequent Co-authors

Simon J. Cook(15), Frank McCormick(14), Paul D. Smith(8), Kathryn Balmanno(7), Harish N. Vasudevan(6), David R. Raleigh(6), Jonathan R. Dry(5), Rebecca Gilley(5), Sydney Lastella(5), Stephen T. Magill(5), Steve Braunstein(5), Arie Perry(5), Line Jacques(5), Alyssa Reddy(5), Melike Pekmezci(5), Pau Castel(4), Alice Cheng(4), Dhirendra K. Simanshu(4), Cyrille L. Delley(4), William Chen(4)