Hisashi Doi

RIKEN Center for Biosystems Dynamics Research — Japan

Medicine · Health Sciences

29h-index2.4kcitations127works0.82yr avg
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Research Topics

Medical Imaging Techniques and Applications(16), Radiopharmaceutical Chemistry and Applications(16), Catalytic Cross-Coupling Reactions(15), Catalytic C–H Functionalization Methods(12), Drug Transport and Resistance Mechanisms(12)

Publications126 total

Metabolic positron emission tomography imaging and tumor growth inhibition during the Q neuron-induced hibernation-like state in mice
Biochemical and Biophysical Research Communications·2026
Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study
Journal of Pharmacological Sciences·2025· 2 citedOpen Access
Chemogenetic activation of mammalian brain neurons expressing insect Ionotropic Receptors by systemic ligand precursor administration
Communications Biology·2024· 1 citedOpen Access
Transient receptor potential cation channel subfamily V member 1 (TRPV1) targeted PET imaging
Japanese Journal of Clinical Oncology·2024
Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats
Frontiers in Immunology·2023· 1 citedOpen Access
In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
EJNMMI Research·2023· 1 citedOpen Access
In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters
Research Square (Research Square)·2023Open Access
Characteristic Evaluation of a <sup>11</sup>C-Labeled Leucine Analog, <scp>l</scp>-α-[5-<sup>11</sup>C]methylleucine, as a Tracer for Brain Tumor Imaging by Positron Emission Tomography
Molecular Pharmaceutics·2023· 3 cited
Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response
Scientific Reports·2023· 6 citedOpen Access
Synthesis and Preclinical Evaluation of <sup>18</sup>F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation.
PubMed·2022· 6 citedOpen Access
Regional neuroinflammation caused by peripheral infection is involved in fatigued symptoms: A [18F]DPA-714 PET study
Research Square (Research Square)·2022Open Access
[18F]DPA-714 PET imaging for the quantitative evaluation of early spatiotemporal changes of neuroinflammation in rat brain following status epilepticus
European Journal of Nuclear Medicine and Molecular Imaging·2022· 16 cited
A Case of Euglycemic Ketoacidosis Triggered by a Cold in a Type 1 Diabetic Patient Taking SGLT2 Inhibitor
Nihon Naika Gakkai Zasshi·2022Open Access
Clinical evaluation of [18F]pitavastatin for quantitative analysis of hepatobiliary transporter activity
Drug Metabolism and Pharmacokinetics·2022· 9 cited
First-in-human assessment of the novel LAT1 targeting PET probe 18F-FIMP
Biochemical and Biophysical Research Communications·2022· 16 cited
[18F]DPA-714 PET Imaging for the Quantitative Evaluation of Early Spatiotemporal Changes of Neuroinflammation in Rat Brain Following Status Epilepticus
2022· 1 citedOpen Access
<i>N</i>-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV1
RSC Medicinal Chemistry·2022· 2 citedOpen Access
PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs
Scientific Reports·2021· 3 citedOpen Access
Front Cover: Synthesis of L‐[5‐<sup>11</sup>C]Leucine and L‐α‐[5‐<sup>11</sup>C]Methylleucine via Pd<sup>0</sup>‐mediated <sup>11</sup>C‐Methylation and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging (ChemMedChem 21/2021)
ChemMedChem·2021
Front Cover: Pd<sup>0</sup>‐Mediated Cross‐Coupling of [<sup>11</sup>C]Methyl Iodide with Carboxysilane for Synthesis of [<sup>11</sup>C]Acetic Acid and its Active Esters: <sup>11</sup>C‐Acetylation of Small, Medium, and Large Molecules (Eur. J. Org. Chem. 29/2021)
European Journal of Organic Chemistry·2021Open Access
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Frequent Co-authors

Yasuyoshi Watanabe(28), Masaaki Suzuki(26), Hirotaka Onoe(16), Yasuhiro Wada(14), Tadayuki Takashima(12), Takamitsu Hosoya(11), Aya Mawatari(9), Hiroko Nagata(8), Yilong Cui(7), Misato Takashima‐Hirano(7), Kayo Onoe(7), Kengo Sumi(6), Miho Shukuri(6), Bengt Långström(6), Hiroko Koyama(6), Yuichi Sugiyama(5), Chihiro Yokoyama(5), Hiroshi Mizuma(4), Ryōji Noyori(4), Kayo Takahashi(4)