Christopher E McMurran

University of Cambridge — United Kingdom

Neuroscience · Life Sciences

18h-index1.5kcitations46works7.32yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(13), Neurogenesis and neuroplasticity mechanisms(10), Multiple Sclerosis Research Studies(9), Immune cells in cancer(7), COVID-19 Clinical Research Studies(5)

Publications39 total

The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy
Trials·2025· 1 citedOpen Access
Ageing and remyelination failure in people with multiple sclerosis
Brain·2025Open Access
Serum neurofilament light chain levels suggest neuroprotection following bexarotene-induced remyelination in people with relapsing remitting multiple sclerosis
Multiple Sclerosis and Related Disorders·2025· 1 citedOpen Access
The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy
2025· 1 citedOpen Access
Brain <scp>DNA</scp> Methylation Age, Lifestyle Factors and Dementia in the Swedish Twin Registry
Aging Cell·2025Open Access
Swedish Twin Registry Brain DNA Methylation Dataset (preprocessed data from EPIC arrays)
2025
Exploratory analysis of biological age measures in a remyelination clinical trial
Brain Communications·2024· 3 citedOpen Access
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
Molecular Neurodegeneration·2024· 28 citedOpen Access
Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination
Nature Communications·2024· 26 citedOpen Access
Bexarotene leads to durable improvements in visual evoked potential latency: A follow-up study of the Cambridge Centre for Myelin Repair One trial
Multiple Sclerosis Journal·2024· 5 citedOpen Access
Visual outcome measures in clinical trials of remyelinating drugs
BMJ Neurology Open·2024· 6 citedOpen Access
Clinical biomarker-based biological ageing and future risk of neurological disorders in the UK Biobank
Journal of Neurology Neurosurgery & Psychiatry·2023· 24 citedOpen Access
Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
2023Open Access
Advanced biological ageing predicts future risk for neurological diagnoses and clinical examination findings
Brain·2023· 19 citedOpen Access
Clinical biomarker-based biological aging and risk of cancer in the UK Biobank
British Journal of Cancer·2023· 136 citedOpen Access
Ageing impairs the regenerative capacity of regulatory T cells in central nervous system remyelination
2023· 3 citedOpen Access
Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells
Immunology and Cell Biology·2022· 10 citedOpen Access
095  Remyelination in people with MS due to an RXR agonist is age-dependent
Journal of Neurology Neurosurgery & Psychiatry·2022
Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent
Annals of Clinical and Translational Neurology·2022· 20 citedOpen Access
A map of transcriptional heterogeneity and regulatory variation in human microglia
Nature Genetics·2021· 222 citedOpen Access
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Frequent Co-authors

Robin J.M. Franklin(12), Adam M. H. Young(9), Alerie Guzman de la Fuente(9), J William L Brown(9), Alasdair Coles(9), Nick Cunniffe(9), Denise Fitzgerald(8), Ramez Kirollos(6), Thomas Santarius(6), Sara Hägg(6), Rosana Peñalva(6), Yvonne Dombrowski(6), Trisha Mukherjee(6), Colin Watts(5), Stephen J. Price(5), Gioia Riboni-Verri(5), Jessica A. White(4), Clare A. Jones(4), Kieren Allinson(4), Michael D. Jenkinson(4)