Richard W. Gross

Washington University in St. Louis — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

89h-index26.5kcitations252works7.02yr avg
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Research Topics

Metabolomics and Mass Spectrometry Studies(64), Mitochondrial Function and Pathology(48), Lipid metabolism and biosynthesis(43), Mass Spectrometry Techniques and Applications(39), Protein Kinase Regulation and GTPase Signaling(32)

Publications252 total

Etomoxir-carnitine, a novel pharmaco-metabolite of etomoxir, inhibits phospholipases A2 and mitochondrial respiration
Journal of Lipid Research·2024· 7 citedOpen Access
Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
iScience·2023· 7 citedOpen Access
Cardiac immune cell infiltration associates with abnormal lipid metabolism
Frontiers in Cardiovascular Medicine·2022· 9 citedOpen Access
The foundations and development of lipidomics
Journal of Lipid Research·2021· 223 citedOpen Access
High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress
Journal of Lipid Research·2021· 18 citedOpen Access
Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice
Nature Metabolism·2020· 146 citedOpen Access
A functional role for eicosanoid-lysophospholipids in activating monocyte signaling
Journal of Biological Chemistry·2020· 22 citedOpen Access
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout
Journal of Biological Chemistry·2020· 26 citedOpen Access
Ketogenic Diet Prevents Heart Failure from Defective Mitochondrial Pyruvate Metabolism
2020· 3 citedOpen Access
Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2–15-HETE lysophospholipids
Journal of Biological Chemistry·2019· 25 citedOpen Access
Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation
Journal of Clinical Investigation·2019· 487 citedOpen Access
Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation
PLoS Biology·2018· 191 citedOpen Access
Cytochrome c is an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl ether linkage
Journal of Biological Chemistry·2018· 70 citedOpen Access
The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization
Nature Communications·2018· 73 citedOpen Access
Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis
Journal of Biological Chemistry·2017· 75 citedOpen Access
Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore
Journal of Biological Chemistry·2017· 49 citedOpen Access
A novel dimeric active site and regulation mechanism revealed by the crystal structure of iPLA <sub>2</sub> β
2017Open Access
calcium-independent phospholipase A2 beta
2017
The evolution of lipidomics through space and time
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2017· 68 citedOpen Access
The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling
Journal of Biological Chemistry·2017· 82 citedOpen Access
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Frequent Co-authors

Xianlin Han(29), Kui Yang(13), Christopher M. Jenkins(6), Daniel P. Kelly(5), David J. Mancuso(5), Hua Cheng(5), Brian N. Finck(4), Jingyue Yang(4), Michael J. Welch(3), Attila Kovács(3), Michael Courtois(3), Nada A. Abumrad(3), Gary J. Patti(3), Stanley L. Hazen(3), John J. Lehman(2), Teresa C. Leone(2), Ray Kozak(2), Gary D. Lopaschuk(2), Harold F. Sims(2), Linda J. Pike(2)