Mari Kono

National Institute of Diabetes and Digestive and Kidney Diseases — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index4.9kcitations104works2.92yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Sphingolipid Metabolism and Signaling(30), Glycosylation and Glycoproteins Research(20), Lysosomal Storage Disorders Research(10), Carbohydrate Chemistry and Synthesis(9), Lipid Membrane Structure and Behavior(6)

Publications104 total

A genome-wide CRISPR/Cas9 screen reveals novel positive regulators of FTY720 sensitivity in acute lymphoblastic leukemia cells
BMC Research Notes·2026Open Access
1-Deoxysphingolipids Require Very-Long-Chain Ceramide Synthesis to Induce ER Stress and Neurotoxicity
2025Open Access
CNS-targeted base editing of the major late-onset Tay-Sachs mutation alleviates disease in mice
Journal of Clinical Investigation·2025· 1 citedOpen Access
Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells
Cell·2025· 12 cited
Effects of culture media on gene expression in reconstructed human epidermis and THP-1 monocytes for skin sensitization evaluation in co-culture systems
Toxicology in Vitro·2025
Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease
Neurobiology of Disease·2024· 1 citedOpen Access
Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation
Advanced Science·2024· 6 citedOpen Access
SARS‐CoV‐2 ORF3a expression in brain disrupts the autophagy–lysosomal pathway, impairs sphingolipid homeostasis, and drives neuropathogenesis
The FASEB Journal·2023· 19 citedOpen Access
Gene expression changes in <scp>Tay–Sachs</scp> disease begin early in fetal brain development
Journal of Inherited Metabolic Disease·2023· 9 citedOpen Access
Visualizing Sphingosine-1-Phosphate Receptor 1(S1P1) Signaling During Central Nervous System De- and Remyelination
Cellular and Molecular Neurobiology·2022· 5 citedOpen Access
Identification of two lipid phosphatases that regulate sphingosine-1-phosphate cellular uptake and recycling
Journal of Lipid Research·2022· 13 citedOpen Access
Storage of GM2 ganglioside and altered gene expression in infantile Tay-Sachs disease during fetal development has implications for therapeutic timing and efficacy
Molecular Genetics and Metabolism·2022
Visualizing Sphingosine-1-Phosphate Receptor 1(S1P1) Signaling During Central Nervous System De- and Re-Myelination
2021Open Access
Genetic defects in the sphingolipid degradation pathway and their effects on microglia in neurodegenerative disease
Cellular Signalling·2020· 33 citedOpen Access
Endothelial S1P <sub>1</sub> Signaling Counteracts Infarct Expansion in Ischemic Stroke
Circulation Research·2020· 137 citedOpen Access
Erratum to “MRI Heating Reduction for External Fixation Devices Using Absorption Material” [Aug 15 635-642]
IEEE Transactions on Electromagnetic Compatibility·2020
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
eLife·2020· 44 citedOpen Access
A genome-wide CRISPR/Cas9 screen reveals that the aryl hydrocarbon receptor stimulates sphingolipid levels
Journal of Biological Chemistry·2020· 42 citedOpen Access
Author response: Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
2019Open Access
The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice
eLife·2019· 74 citedOpen Access
page 1 of 6Next →

Frequent Co-authors

Richard L. Proia(22), Shuichi Tsuji(8), María L. Allende(7), Timothy Hla(7), Koji Ohara(6), Shou Takashima(5), Tadashi Yamashita(4), Norbert Werth(4), Roger Sandhoff(4), Konrad Sandhoff(4), Nobuyuki Kurosawa(4), Saurav Majumder(4), Hongling Zhu(4), Colleen Byrnes(4), Galina Tuymetova(4), Hiroki Mizukami(3), Yide Mi(3), Yujing Liu(3), Sylvain Galvani(3), Eric Engelbrecht(3)