Tomoko Ise

National Institute of Biomedical Innovation, Health and Nutrition — Japan

Medicine · Health Sciences

29h-index2.7kcitations63works1.82yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(20), Toxin Mechanisms and Immunotoxins(10), Chronic Lymphocytic Leukemia Research(9), T-cell and B-cell Immunology(7), Lymphoma Diagnosis and Treatment(7)

Publications63 total

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule
Antibody Therapeutics·2025· 1 citedOpen Access
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
PLoS ONE·2024· 2 citedOpen Access
Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule
2024· 1 citedOpen Access
Crystal structures of human CD40 in complex with monoclonal antibodies dacetuzumab and bleselumab
Biochemical and Biophysical Research Communications·2024· 1 citedOpen Access
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo
2024· 4 citedOpen Access
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by reducing signaling activity through epitope selection
Communications Biology·2023· 9 citedOpen Access
Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection
2022· 2 citedOpen Access
Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing
Scientific Reports·2021· 10 citedOpen Access
Preclinical development of anti-BCMA immunotoxins targeting multiple myeloma
Antibody Therapeutics·2018· 9 citedOpen Access
Clinical significance of MUC13 in pancreatic ductal adenocarcinoma
HPB·2018· 32 citedOpen Access
Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients
Leukemia·2017· 11 citedOpen Access
Abstract 4592: MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression
Cancer Research·2016
MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression
Oncogene·2016· 34 citedOpen Access
CD21<sup>−/low</sup> Marginal Zone B Cells Highly Express Fc Receptor–like 5 Protein and Are Killed by Anti–Fc Receptor–like 5 Immunotoxins in Hepatitis C Virus–Associated Mixed Cryoglobulinemia Vasculitis
Arthritis & Rheumatology·2013· 19 citedOpen Access
CD164 and FCRL3 Are Highly Expressed on CD4+CD26 − T Cells in Sézary Syndrome Patients
Journal of Investigative Dermatology·2013· 39 citedOpen Access
OP0194 CD21-/LO Marginal Zone-Like B Cells in HCV-Related Mixed Cryoglobulinemia Vasculitis Highly Express FCRL5 Protein and are Specifically Killed by Anti-FCRL5 Immunotoxins
Annals of the Rheumatic Diseases·2013
Two functional ligand binding sites on human CD30 separately located from the epitope of agonistic monoclonal antibodies (P6339)
The Journal of Immunology·2013
Laborsaving production of site-specific anti-phospho monoclonal antibodies by simultaneous screening for multiple phosphopeptides using multiplex bead assay (P3372)
The Journal of Immunology·2013
Human Fc Receptor–Like 5 Binds Intact IgG via Mechanisms Distinct from Those of Fc Receptors
The Journal of Immunology·2013· 74 citedOpen Access
Les lymphocytes B clonaux et autoréactifs au cours des cryoglobulinémies mixtes associées au virus de l’hépatite C expriment fortement le marqueur FCRL5 et sont détruits spécifiquement par des immunotoxines anti-FCRL5
La Revue de Médecine Interne·2012
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Frequent Co-authors

Satoshi Nagata(26), Hiroto Izumi(17), Kimitoshi Kohno(17), Ira Pastan(14), Minoru Nomoto(10), Gunji Nagatani(8), Hidetaka Uramoto(7), Tadashi Murakami(7), Mizuho Tanabe(6), Toshihiro Imamura(6), Haruhiko Kamada(6), Takayuki Torigoe(5), Hiroshi Ishiguchi(5), Yoichiro Yoshida(5), Ken Kato(5), Hiroshi Takano(5), Tapan K. Bera(5), Kouhei Tsumoto(5), Hiroki Akiba(4), Hiroaki Ohno(4)