Hariharan Saminathan

Medicine · Health Sciences

9h-index631citations13works0.02yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(6), Nerve injury and regeneration(4), Neuroinflammation and Neurodegeneration Mechanisms(4), Retinal Development and Disorders(2), PI3K/AKT/mTOR signaling in cancer(2)

Publications13 total

2178-LB: BI-4659, an Adipose Tissue–Enriched Mitochondrial Uncoupler, Reverses Diet-Induced Obesity in Mice
Diabetes·2025
Pharmacological Inhibition of PTEN Rescues Dopaminergic Neurons by Attenuating Apoptotic and Neuroinflammatory Signaling Events
Journal of Neuroimmune Pharmacology·2023· 5 cited
Pharmacological inhibition of PTEN rescues dopaminergic neurons by attenuating apoptotic and neuroinflammatory signalling events
2022Open Access
Environmental neurotoxicants and inflammasome activation in Parkinson’s disease – A focus on the gut-brain axis
The International Journal of Biochemistry & Cell Biology·2021· 11 cited
Perspectives on the use and risk of adverse events associated with cytokine-storm targeting antibodies and challenges associated with development of novel monoclonal antibodies for the treatment of COVID-19 clinical cases
Human Vaccines & Immunotherapeutics·2021· 9 citedOpen Access
Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease
Frontiers in Pharmacology·2021· 13 citedOpen Access
Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research
European Journal of Pharmacology·2020· 27 citedOpen Access
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
The Journal of Experimental Medicine·2019· 238 cited
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Journal of Neuroscience·2015· 163 citedOpen Access
Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson’s disease (1055.7)
The FASEB Journal·2014· 9 cited
The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons
Journal of Biological Chemistry·2013· 79 citedOpen Access
Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote pkcδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model
NeuroToxicology·2011· 38 citedOpen Access
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration
Molecular Neurodegeneration·2011· 39 citedOpen Access

Frequent Co-authors

Anumantha G. Kanthasamy(9), Arthi Kanthasamy(7), Huajun Jin(6), Vellareddy Anantharam(6), Richard D. Gordon(5), Nikhil Panicker(4), Aishwarya Mary Johnson(4), Dilshan S. Harischandra(3), Souvarish Sarkar(2), Adhithiya Charli(2), Kavin Kanthasamy(2), Jie Luo(2), Anamitra Ghosh(2), Arunkumar Asaithambi(2), Sara Jose(2), Mir Azam Khan(2), Jaleel Kizhakkayil(2), Mark G. H. Scott(2), Matthew Neal(1), Tae‐In Kam(1)