Derek F. Ceccarelli

Mount Sinai Hospital — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index4.8kcitations66works6.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(27), Protein Degradation and Inhibitors(11), Cancer-related Molecular Pathways(8), Cell Adhesion Molecules Research(8), RNA and protein synthesis mechanisms(7)

Publications66 total

Author Correction: A substrate binding model for the KEOPS tRNA modifying complex
Nature Communications·2025Open Access
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation
Nature Communications·2024· 16 citedOpen Access
A Novel Confocal Scanning Protein–Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin
Bioconjugate Chemistry·2024· 2 citedOpen Access
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4
Journal of Medicinal Chemistry·2022· 50 citedOpen Access
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme–ubiquitin complex
Science Advances·2021· 30 citedOpen Access
Crystal Structure of the FERM Domain of Focal Adhesion Kinase
UNC Libraries·2021Open Access
Bipartite binding of the N terminus of Skp2 to cyclin A
Structure·2021· 10 citedOpen Access
N-terminus of Skp2 bound to Cyclin A
2021
A substrate binding model for the KEOPS tRNA modifying complex
Nature Communications·2020· 31 citedOpen Access
Structural Basis for the Autoinhibition of Focal Adhesion Kinase
UNC Libraries·2020Open Access
KEOPS tRNA modifying sub-complex of archaeal Cgi121 and tRNA
2020
Cgi121-tRNA complex
2020
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients
Science Immunology·2020· 907 citedOpen Access
Functional characterization of a PROTAC directed against BRAF mutant V600E
Nature Chemical Biology·2020· 128 citedOpen Access
Mucosal versus systemic antibody responses to SARS-CoV-2 antigens in COVID-19 patients
2020· 54 citedOpen Access
Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes
Journal of Molecular Biology·2019· 33 citedOpen Access
FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane
Structure·2019· 13 citedOpen Access
Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15
Structure·2019· 59 citedOpen Access
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
Nature Communications·2018· 78 citedOpen Access
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
BMC Biology·2018· 12 citedOpen Access
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Frequent Co-authors

Frank Sicheri(37), Stephen Orlicky(14), Anne‐Claude Gingras(10), Mike Tyers(8), Michael J. Eck(7), Daniel Durocher(7), Igor Kurinov(7), Michael D. Schaller(6), Jeffrey L. Wrana(5), Xiaojing Tang(5), Daniel Y.L. Mao(5), Yu‐Chi Juang(4), Rachel K. Szilard(4), Lori Frappier(4), Marilyn Goudreault(4), Elton Zeqiraj(4), Pierre Maisonneuve(4), Daniel J. St‐Cyr(4), Lauren Caldwell(3), Karen Colwill(3)