Kirsti Hornigold

Babraham Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index166citations13works1.52yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(5), PI3K/AKT/mTOR signaling in cancer(4), Neuropeptides and Animal Physiology(3), Receptor Mechanisms and Signaling(3), Signaling Pathways in Disease(3)

Publications13 total

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity
Cell Reports·2025Open Access
P-Rex1 Limits the Agonist-Induced Internalisation of GPCRs Independently of its Rac-GEF Activity
2025· 3 citedOpen Access
The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Frontiers in Immunology·2023· 6 citedOpen Access
Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
Small GTPases·2022· 17 citedOpen Access
Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Frontiers in Immunology·2022· 26 citedOpen Access
Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
Figshare·2022Open Access
The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
Blood Advances·2021· 18 citedOpen Access
P-Rex1
2017· 6 cited
P-Rex2
2017· 3 cited
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
Proceedings of the National Academy of Sciences·2016· 56 citedOpen Access
Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1
Journal of Biological Chemistry·2016· 30 citedOpen Access
P-Rex2
2016
P-Rex1
2016· 1 cited

Frequent Co-authors

Heidi C. E. Welch(11), Chiara Pantarelli(7), Elpida Tsonou(6), Martin J. Baker(5), Dingxin Pan(4), David Oxley(3), Stephen A. Chetwynd(3), Polly A. Machin(3), Laraine Crossland(3), Anne Segonds-Pichon(3), Elizabeth Hampson(3), Priota Islam(3), Rachael Walker(2), Campbell D. Lawson(2), Izabella Niewczas(2), Simon Andrews(2), J. Clark(2), HCE Welch(2), Angeliki Malliri(2), Ruben Pelaez Moral(2)