Timothy M. Willson

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

110h-index68.6kcitations415works3.52yr avg
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Research Topics

Peroxisome Proliferator-Activated Receptors(98), Estrogen and related hormone effects(59), Drug Transport and Resistance Mechanisms(57), Cholesterol and Lipid Metabolism(44), Computational Drug Discovery Methods(41)

Publications414 total

N ‑Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity
UNC Libraries·2025Open Access
A new emerging target for treating multiple sclerosis: DRAK2 deficiency remodels lipid and cholesterol composition to favor Treg expansion 4779
The Journal of Immunology·2025Open Access
Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity
RSC Medicinal Chemistry·2025Open Access
Author response for "Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity"
2025
<i> <b>N</b> </i> -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Identification and Optimization of 4‐Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
UNC Libraries·2025Open Access
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma
Blood·2025· 1 citedOpen Access
Identification of Spirodioxolane nsP2 Helicase Inhibitors with Antialphaviral Activity
2025Open Access
Protein–ligand data at scale to support machine learning
Nature Reviews Chemistry·2025· 7 cited
Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity
ACS Infectious Diseases·2025· 3 citedOpen Access
Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2
2025Open Access
Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity
Journal of Medicinal Chemistry·2025· 5 citedOpen Access
<i>N</i> -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity
2025· 1 citedOpen Access
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
UNC Libraries·2025Open Access
A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity
UNC Libraries·2025Open Access
Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity
UNC Libraries·2025Open Access
Structural Chemistry of Helicase Inhibition
UNC Libraries·2025Open Access
STOPLIGHT: A Hit Scoring Calculator
UNC Libraries·2025Open Access
Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase
2025· 3 citedOpen Access
Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
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Frequent Co-authors

Steven A. Kliewer(27), Linda B. Moore(13), Millard H. Lambert(11), Jürgen M. Lehmann(10), Derek J. Parks(10), Stacey A. Jones(10), Jon L. Collins(9), David D. McKee(8), John T. Moore(8), Bryan Goodwin(7), Christopher K. Glass(6), G. Bruce Wisely(6), H. Eric Xu(6), Valerie G. Montana(6), Kelli D. Plunket(6), Randy K. Bledsoe(5), Andrew C. Li(4), Steven G. Blanchard(4), Thomas G. Consler(4), Julie B. Stimmel(4)