Miki Shimohigashi

Fukuoka University — Japan

Neuroscience · Life Sciences

15h-index786citations93works1.02yr avg
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Research Topics

Neurobiology and Insect Physiology Research(43), Circadian rhythm and melatonin(30), Insect and Arachnid Ecology and Behavior(23), Estrogen and related hormone effects(15), Effects and risks of endocrine disrupting chemicals(7)

Publications93 total

The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins
PLoS ONE·2024· 1 citedOpen Access
ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ
Toxicology Letters·2021· 12 cited
Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding
PLoS ONE·2021· 13 citedOpen Access
Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities
Bioorganic & Medicinal Chemistry·2019· 21 citedOpen Access
Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors
Toxicology and Applied Pharmacology·2019· 73 cited
ヒト核受容体に対するビスフェノールAとその次世代類似体の受容体結合親和性【JST・京大機械翻訳】
Toxicology and Applied Pharmacology·2019
Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface
2018
Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization
2018
Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand
2018
Inactive AF1 domain-lacking ERα isomer is activated by constitutively active human nuclear receptor ERRα and ERRγ
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2017
Transcriptional activity of thyroid hormone receptors are reinforced strongly by constitutively self-activating nuclear receptors
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2017
Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster
2016
α‐Helix‐peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization
Biopolymers·2015· 4 cited
Comparative analyses of mRNA genes of circadian pacemaker hormone peptide PDF in the hypoactive and hyperactive fruit fly Drosophila melanogaster
The Japanese Biochemical Society/The Molecular Biology Society of Japan·2015
The molecular switching of ORL1 nociceptin receptor in activation/inactivation
2015
Bisphenol A-Induced Substantial Peak Decay of Drosophila Circadian Neuropeptide hugin mRNA Expression
Biopolymers·2015
A Characteristic Back Support Structure in the Bisphenol A-Binding Pocket in the Human Nuclear Receptor ERRγ
PLoS ONE·2014· 19 citedOpen Access
Neuronal Projections and Putative Interaction of Multimodal Inputs in the Subesophageal Ganglion in the Blowfly, Phormia regina
Chemical Senses·2014· 13 citedOpen Access
Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies
2014
An in vivo Multi-Generation Propagation Assay for Endocrine Disrupting Chemicals in the Fruit Fly Drosophila melanogaster : Reproductive Functions Disrupted by 4-Nonylphenol
Medical Entomology and Zoology·2013Open Access
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Frequent Co-authors

Yasuyuki Shimohigashi(37), Ayami Matsushima(29), Yoshiya Tominaga(16), Yukimasa Takeda(15), Seiji Sato(14), Takeru Nose(10), Yoshiro Chuman(10), Kazunori Sumida(7), Satoru Yokotani(6), Miho Sumiyoshi(6), Keita Koga(6), Ian A. Meinertzhagen(5), Takeshi Honda(5), Keitaro Suyama(4), Naoto Shirasu(4), Yutaka Matsuyama(4), Atsushi Kaneki(4), Xiaohui Liu(3), Hiroyuki Okada(3), Xiaohui Liu(3)