Karina Bursch

Medical College of Wisconsin — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index151citations17works5.82yr avg
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Research Topics

Protein Degradation and Inhibitors(8), Multiple Myeloma Research and Treatments(3), Wnt/β-catenin signaling in development and cancer(3), Skin and Cellular Biology Research(3), Chromatin Remodeling and Cancer(3)

Publications17 total

BRD4 represses developmental and neuronal genes through interactions with polycomb complexes
2026Open Access
Polybromo-1 Bromodomain Inhibitor Selectivity Is Mediated by a Unique Ligand-Binding Pocket
ACS Medicinal Chemistry Letters·2025Open Access
BET bromodomain inhibitors attenuate transcription of a subset of IL-1-induced NF-κB targets that promote inflammation in β-cells
Journal of Biological Chemistry·2025· 3 citedOpen Access
Abstract 2463 BET bromodomain inhibitors selectively attenuate IL-1-induced transcription of NF-κB targets in pancreatic β-cells
Journal of Biological Chemistry·2025Open Access
Abstract 1807 Polybromo-1 bromodomain missense variants associated with clear cell renal cell carcinoma exhibit variable biochemical fitness
Journal of Biological Chemistry·2025Open Access
Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains
Journal of Biological Chemistry·2025· 2 citedOpen Access
Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression
Journal of Biological Chemistry·2024· 6 citedOpen Access
Current Trends in Sirtuin Activator and Inhibitor Development
Molecules·2024· 35 citedOpen Access
Abstract 1294: Cancer-associated missense mutations in the tumor suppressor Polybromo-1 variably affect protein stability and function
Journal of Biological Chemistry·2023Open Access
Analysis of continuous enzyme kinetic data using ICEKAT
Methods in enzymology on CD-ROM/Methods in enzymology·2023· 6 citedOpen Access
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening
Journal of Medicinal Chemistry·2022· 20 citedOpen Access
Polybromo‐1 missense mutations found in renal cancer patients affect bromodomain stability and biological function
The FASEB Journal·2022
Revisiting biochemistry: severe euglycemic ketoacidosis in the setting of IDH‐inhibitor therapy for AML
British Journal of Haematology·2021· 1 cited
Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells
Cell Adhesion & Migration·2021· 28 citedOpen Access
Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells
2020Open Access
Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors
Scientific Reports·2019· 50 citedOpen Access
Oral Carbon Monoxide Therapy in Murine Models of Sickle Cell Disease: Beneficial Effects on Vaso-Occlusion, Inflammation and Anemia
Blood·2017

Frequent Co-authors

Brian C. Smith(8), Raymundo Nuñez(6), Michael D. Olp(6), Christopher G. Goetz(5), Emily C. Dykhuizen(4), Raúl Urrutia(4), Pooja Sharma(3), Sarah Alsharif(3), Arwa Fallatah(3), Byung Min Chung(3), Guanming Jiao(3), Brian D. Smith(3), Rachel Milliken(2), Van Lam(2), Thuc Phan(2), Meagan Collins(2), Priya Dohlman(2), Georges Nehmetallah(2), Christopher B. Raub(2), Shifali Shishodia(2)