Margaret Y. Chu‐Moyer

Amgen (United States) — United States

Chemistry · Physical Sciences

19h-index967citations36works3.02yr avg
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Research Topics

Chemical synthesis and alkaloids(8), Oxidative Organic Chemistry Reactions(4), Bioactive Compounds and Antitumor Agents(4), Receptor Mechanisms and Signaling(3), Synthetic Organic Chemistry Methods(3)

Publications36 total

Antiviral target compound profile for pandemic preparedness
Nature Reviews Drug Discovery·2024· 3 citedOpen Access
CCDC 1947050: Experimental Crystal Structure Determination
The Cambridge Structural Database·2019Open Access
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition
Bioorganic & Medicinal Chemistry Letters·2018· 11 citedOpen Access
The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement
Bioorganic & Medicinal Chemistry Letters·2017· 20 citedOpen Access
Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity
Journal of Medicinal Chemistry·2017· 66 citedOpen Access
Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
Correction to “Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable <i>in Vivo</i> Target Engagement”
ACS Medicinal Chemistry Letters·2017
Sulfonamides as Selective Na<sub>V</sub>1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement
ACS Medicinal Chemistry Letters·2016· 37 citedOpen Access
Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective Na<sub>V</sub>1.7 Inhibitors
Journal of Medicinal Chemistry·2016· 42 citedOpen Access
Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists
Bioorganic & Medicinal Chemistry Letters·2012· 14 citedOpen Access
CCDC 855714: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats
Bioorganic & Medicinal Chemistry Letters·2006· 24 citedOpen Access
SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711
Bioorganic & Medicinal Chemistry Letters·2002· 7 citedOpen Access
Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors:  Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines
Journal of Medicinal Chemistry·2001· 48 citedOpen Access
Patent focus on antidiabetic agents: September 1999 - February 2000
Expert Opinion on Therapeutic Patents·2000· 1 cited
Total Synthesis of (+)-Myrocin C
1997· 2 cited
ChemInform Abstract: Preparation of the Four Regioisomeric 2‐(Methylthio)oxazolopyridines: Useful Synthons for Elaboration to 2‐(Amino‐substituted) oxazolopyridines.
ChemInform·1996
Preparation of the Four Regioisomeric 2-(Methylthio)oxazolopyridines: Useful Synthons for Elaboration to 2-(Amino substituted)oxazolopyridines
The Journal of Organic Chemistry·1995· 24 cited
ChemInform Abstract: Total Synthesis of (.+‐.)‐Myrocin C ((.+‐.)‐XI).
ChemInform·1995
A Remarkable Glycosidation Reaction: The Total Synthesis of Calicheamicin .gamma.1I
Journal of the American Chemical Society·1995· 59 cited
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Frequent Co-authors

Samuel J. Danishefsky(14), Erin F. DiMauro(8), Robert T. Fremeau(8), Hua Gao(8), Hakan Günaydin(8), Joseph Ligutti(8), Violeta Yu(8), Bryan D. Moyer(8), Matthew M. Weiss(8), R. Foti(7), Angel Guzmán-Pérez(7), Thomas Kornecook(7), Daniel S. La(7), Emily A. Peterson(7), Thomas A. Dineen(6), Charles R. Kreiman(6), Min-Hwa Jasmine Lin(6), Isaac E. Marx(6), Gayle K. Schulte(5), Russell F. Graceffa(5)