Mizuho Une

Hiroshima International University — Japan

Medicine · Health Sciences

23h-index1.8kcitations92works1.52yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(68), Cholesterol and Lipid Metabolism(25), Metabolism and Genetic Disorders(15), Peroxisome Proliferator-Activated Receptors(11), Liver Disease Diagnosis and Treatment(10)

Publications92 total

FLG249 Exhibits FXR Antagonist Activity by Inducing Dissociation of Both Corepressors and Coactivators from FXR
Biological and Pharmaceutical Bulletin·2025Open Access
Molecular mechanisms of hepatitis B virus entry inhibition by a bile acid derivative INT-767 binding to the preS1 region
Antiviral Research·2025· 1 cited
Fecal fatty acid-linked bile acid profiles in pediatric patients with ulcerative colitis
Clinica Chimica Acta·2024· 1 cited
FXR Antagonist FLG249 Lowers Hepatic Triacylglycerol and Serum Cholesterol Level in High-Fat Diet-Induced Obese Mice
Biological and Pharmaceutical Bulletin·2024· 4 citedOpen Access
Discovery of FXR/PPARγ dual partial agonist
Bioorganic & Medicinal Chemistry·2023· 9 citedOpen Access
Hyodeoxycholic Acid (HDCA) Prevents Development of Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice: Possible Role of Synergism between DSS and HDCA in Increasing Fecal Bile Acid Levels
Biological and Pharmaceutical Bulletin·2022· 14 citedOpen Access
Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum
ACS Medicinal Chemistry Letters·2021· 18 citedOpen Access
Dual Agonist of Farnesoid X Receptor and Takeda G Protein‐Coupled Receptor 5 Inhibits Hepatitis B Virus Infection In Vitro and In Vivo
Hepatology·2021· 38 cited
N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR)
Bioorganic & Medicinal Chemistry·2020· 10 citedOpen Access
Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists
Bioorganic & Medicinal Chemistry·2019· 10 citedOpen Access
Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the <i>CYP27A1</i> Gene
Internal Medicine·2018· 8 citedOpen Access
Nonacidic Chemotype Possessing <i>N</i>-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists
ACS Medicinal Chemistry Letters·2018· 15 citedOpen Access
Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β‐Muricholic Acid, a Farnesoid X Receptor Antagonist
Lipids·2017· 25 cited
Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists
Bioorganic & Medicinal Chemistry·2017· 8 citedOpen Access
A novel varanic acid epimer – (24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid – is a major biliary bile acid in two varanid lizards and the Gila monster
Steroids·2012· 5 cited
Biliary bile acids in birds of the Cotingidae family: Taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid
Steroids·2011· 4 cited
Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation
Biological and Pharmaceutical Bulletin·2011· 40 citedOpen Access
Major Biliary Bile Acids of the Medaka (<i>Oryzias latipes</i>): 25<i>R</i>- and 25<i>S</i>-Epimers of 3α,7α,12α-Trihydroxy-5β-cholestanoic Acid
ZOOLOGICAL SCIENCE·2010· 9 citedOpen Access
Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor
Journal of Lipid Research·2009· 35 citedOpen Access
Structure–activity relationship of bile alcohols as human farnesoid X receptor agonist
Steroids·2009· 21 cited
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Frequent Co-authors

Takahiko Hoshita(17), Yusuke Iguchi(10), Kenji Kihira(9), Tomoko Nishimaki‐Mogami(9), T Kuramoto(8), Bertram I. Cohen(5), Yukiko Yamashita(5), Kazuhide Inoue(4), T Hoshita(4), E.H. Mosbach(4), Erwin H. Mosbach(4), Naoki Teno(4), Ko Fujimori(4), Keigo Gohda(4), Taiju Kuramoto(3), Tomofumi Fujino(3), N Matoba(3), S Kuroki(3), Charles K. McSherry(3), Keisuke Oda(3)