Guillaume Duvey

Prexton Therapeutics (Switzerland) — Switzerland

Neuroscience · Life Sciences

10h-index307citations20works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(10), Receptor Mechanisms and Signaling(6), Catalytic Cross-Coupling Reactions(4), Synthesis and Catalytic Reactions(4), Catalytic C–H Functionalization Methods(3)

Publications20 total

An m<scp>G</scp>lu4‐<scp>P</scp>ositive <scp>A</scp>llosteric <scp>M</scp>odulator <scp>A</scp>lleviates <scp>P</scp>arkinsonism in <scp>P</scp>rimates
Movement Disorders·2018· 57 cited
Characterization of [11C]PXT012253 as a PET Radioligand for mGlu4 Allosteric Modulators in Nonhuman Primates
Molecular Imaging and Biology·2018· 14 cited
Noise-Induced Hearing Loss in Mice: Effects of High and Low Levels of Noise Trauma in CBA Mice
2018· 12 cited
A Novel mglur4 compound alleviates motor symptoms in primate models of parkinson's disease
Journal of the Neurological Sciences·2017· 2 cited
Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 <i>H</i> )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Journal of Medicinal Chemistry·2014· 56 citedOpen Access
A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core
Bioorganic & Medicinal Chemistry Letters·2013· 6 citedOpen Access
Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Journal of Medicinal Chemistry·2012· 34 citedOpen Access
mGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders
Annual reports in medicinal chemistry·2012· 6 cited
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Bioorganic & Medicinal Chemistry Letters·2010· 19 citedOpen Access
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones
MedChemComm·2010· 10 cited
Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
ACS Chemical Neuroscience·2010· 25 cited
Synthesis of 3‐Fluoroazetidines.
ChemInform·2006Open Access
Synthesis of 3-Fluoroazetidines
The Journal of Organic Chemistry·2006· 27 cited
ChemInform Abstract: ortho‐Directed Metallation of π‐Deficient Heterocycles in Connection with Palladium‐Catalyzed Biaryl Cross‐Coupling — Synthesis of Marine Alkaloids of the Pyridoacridine Series
ChemInform·2002
ChemInform Abstract: Reactivity of 4‐Chlorobenzo[c][2,7]naphthyridines Towards Pd(0) Catalyzed Coupling Reactions and Nucleophilic Substitutions. Aroylation by Nucleophilic Substitution with Analogues of Acyl Anions.
ChemInform·2002
Ortho-directed metallation of π-deficient heterocycles in connection with palladium-catalyzed biaryl cross-coupling Synthesis of marine alkaloids of the pyridoacridine series
Canadian Journal of Chemistry·2001· 11 cited
Reactivity of 4‐chlorobenzo[<i>c</i>][2,7]naphthyridines towards Pd(0) catalyzed coupling reactions and nucleophilic substitutions. aroylation by nucleophilic substitution with analogues of acyl anions
Journal of Heterocyclic Chemistry·2001· 9 cited
ChemInform Abstract: A New Entry Towards the Synthesis of 1‐Substituted 3‐Azetidinones.
ChemInform·2001
A new entry towards the synthesis of 1-substituted 3-azetidinones
Tetrahedron Letters·2001· 19 cited
Etude de la fonctionnalisation du système benzo[c][2,7]naphtyridine par voie organométallique, en vue de l'obtention de molécules polyaromatiques biologiquement actives
2000

Frequent Co-authors

Jean‐Philippe Rocher(7), Sonia Poli(7), José M. Cid(5), Robert Lütjens(5), José Ignacio Andrés(5), Gregor J. Macdonald(5), Hilde Lavreysen(5), Andrés A. Trabanco(5), Delphine Charvin(4), Terry Finn(4), Vanthea Nhem(4), Philippe Cluzeau(4), Dirk De Smaele(4), Norbert De Kimpe(4), Emmanuel Le Poul(4), Alain Godard(4), Patrick Rocca(4), F. Nivoliers(4), Francis Marsais(4), G. QUEGUINER(4)