Nathan D. Trinklein

Chrono Therapeutics (United States) — United States

Medicine · Health Sciences

32h-index11.9kcitations61works1.32yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Monoclonal and Polyclonal Antibodies Research(25), CAR-T cell therapy research(20), Genomics and Chromatin Dynamics(15), RNA Research and Splicing(10), RNA and protein synthesis mechanisms(9)

Publications60 total

889 Comprehensive characterization of RNDO-564, a first-in-class CD28 x Nectin-4 bispecific antibody for the treatment of solid tumors
Regular and Young Investigator Award Abstracts·2025Open Access
Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers
Journal for ImmunoTherapy of Cancer·2025· 3 citedOpen Access
A novel CD28 x Nectin-4 costimulatory bispecific antibody for advanced bladder cancer.
Journal of Clinical Oncology·2025· 1 cited
939 A novel CD28 x Nectin-4 costimulatory bispecific antibody targeting metastatic bladder cancer
Regular and Young Investigator Award Abstracts·2024· 1 citedOpen Access
A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer
OncoImmunology·2022· 16 citedOpen Access
Abstract 6244: A T cell engaging bispecific antibody utilizing a bivalent tumor-selective folate receptor alpha binding arm for the treatment of ovarian cancer
Cancer Research·2022
Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release
Journal for ImmunoTherapy of Cancer·2021· 65 citedOpen Access
A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
Scientific Reports·2021· 34 citedOpen Access
TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
mAbs·2021· 35 citedOpen Access
A CD3 x FRα T-cell engaging bispecific antibody for efficient killing of ovarian cancer cells with minimal cytokine release.
Journal of Clinical Oncology·2020· 1 cited
Perspective: Designing T-Cell Engagers With Better Therapeutic Windows
Frontiers in Oncology·2020· 78 citedOpen Access
Author Correction: Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Nature Communications·2020· 6 citedOpen Access
Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Nature Communications·2020· 120 citedOpen Access
TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion
Blood·2019· 6 cited
T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma
Blood·2019· 45 cited
Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies
Immunology·2019
Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies
Cancer Research·2019
Evaluation of monovalent versus biparatopic CD3xPSMA bispecific antibodies for t-cell mediated killing of prostate tumor cells with minimal cytokine release.
Journal of Clinical Oncology·2019
A novel CD3xPSMA bispecific antibody for efficient T cell mediated killing of prostate tumor cells with minimal cytokine release.
Journal of Clinical Oncology·2019· 2 cited
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
mAbs·2019· 98 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

Shelley Force Aldred(25), Katherine E. Harris(18), R Myers(17), Ute Schellenberger(17), Laura Davison(17), Harshad S. Ugamraj(16), Duy Pham(15), Starlynn Clarke(15), Ben Buelow(14), Kevin Dang(14), Udaya S. Rangaswamy(14), Andrew Boudreau(13), Wim van Schooten(11), Suhasini Iyer(10), Brett Jorgensen(10), Patrick Collins(9), Payal Pratap(9), Roland Buelow(9), Aarti Balasubramani(9), Heather Ogana(7)