Jennifer S. Isaacs

University of Kentucky — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index5.2kcitations49works0.02yr avg
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Research Topics

Heat shock proteins research(23), Cancer, Hypoxia, and Metabolism(10), Cancer-related Molecular Pathways(6), ATP Synthase and ATPases Research(6), Epigenetics and DNA Methylation(5)

Publications49 total

Methodology of INDICATE: Investigating Neuromarkers for Decline & Impairment of Cognition After Thrombectomy for ELVO
Alzheimer s & Dementia·2024Open Access
The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
Clinical Cancer Research·2019· 368 citedOpen Access
Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling
Oncotarget·2017· 12 citedOpen Access
Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity
Oncotarget·2016· 39 citedOpen Access
Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS
Journal of Proteome Research·2016· 39 citedOpen Access
Preface
Advances in cancer research·2016· 3 cited
Hsp90 as a “Chaperone” of the Epigenome
Advances in cancer research·2015· 27 cited
Abstract 1448: Dynamic chromatin modification by tumor secreted Hsp90 modulates EMT and tumor invasion
Cancer Research·2015
Tumor-secreted Hsp90 Subverts Polycomb Function to Drive Prostate Tumor Growth and Invasion
Journal of Biological Chemistry·2015· 75 citedOpen Access
Extracellular Hsp90 as a Novel Epigenetic of EMT and Metastatic Risk in Prostate Cancer
2014
The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer
Cancers·2014· 60 citedOpen Access
Extracellular Hsp90 as a Novel Epigenetic Regulator of EMT and Metastatic Risk in Prostate Cancer
2013
Abstract A74: Tumor secreted Hsp90 initiates tumor growth and the epithelial to mesenchymal transition (EMT) in prostate cancer
Cancer Research·2013
Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer
Journal of Biological Chemistry·2012· 146 citedOpen Access
Abstract 348: Extracellular heat shock protein 90 (eHsp90) initiates EMT events and enhances cell motility in prostate cancer
Cancer Research·2012
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation
BMC Cancer·2011· 30 citedOpen Access
A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion
PLoS ONE·2011· 133 citedOpen Access
Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.
PubMed·2011· 4 cited
Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus.
PubMed·2011· 23 citedOpen Access
Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV
Virology·2010· 34 cited
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Frequent Co-authors

Len Neckers(10), Udhayakumar Gopal(10), Michael W. Hance(8), Jessica Bohonowych(8), Yunjin Jung(6), Krystal D. Nolan(6), Sunmin Lee(5), Jane B. Trepel(5), Michael DeFee(4), Chris Parsons(4), Leonard Μ. Neckers(3), Omar E. Franco(3), Simon W. Hayward(3), J. Carl Barrett(3), Zhiqiang Qin(3), Maria J. Merino(2), Berton Zbar(2), Jorge R. Toro(2), W. Marston Linehan(2), Edward G. Mimnaugh(2)