W.H. Down

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

9h-index288citations27works0.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(8), Drug Transport and Resistance Mechanisms(4), Drug-Induced Hepatotoxicity and Protection(4), Diet and metabolism studies(4), Cardiovascular Function and Risk Factors(3)

Publications27 total

Absorption and elimination of a branched-chain alkylpolyethoxylate surfactant in rats
Toxicology Letters·1983· 4 cited
The effect of intravenously administered phosphocreatine on ATP and phosphocreatine concentrations in the cardiac muscle of the rat.
PubMed·1983· 19 cited
Effect of the triazolobenzodiazepine estazolam on hepatic drug-metabolizing enzyme activity in rats
Journal of Pharmacy and Pharmacology·1982· 7 cited
The metabolism of the hypolipidaemic drug sultosilic acid in rat, dog and man
Xenobiotica·1982· 2 cited
Metabolic fate of the beta-blocker 14C-bupranolol in humans, dogs, and rhesus monkeys.
Drug Metabolism and Disposition·1982· 9 cited
Induktion und Inhibition des Metabolismus organischer Nitrate
1982
Induction and Inhibition of Organic Nitrate Metabolism
1981
Factors affecting induction of lung aryl hydrocarbon hydroxylase in rats exposed to cigarette smoke
Toxicology·1981· 7 cited
Hepatic microsomal drug-metabolizing enzyme activity in non-human primates; the effect of repeated oral administration of DDT to baboons and rhesus monkeys
Comparative Biochemistry and Physiology Part C Comparative Pharmacology·1981· 1 cited
Glutathione S-transferase activity towards benz[a]anthracene 5,6-oxide in the liver, kidney and lung of cynomolgus monkeys
Biochemical Pharmacology·1980· 6 cited
The effect of caffeine on the absorption of 3H-dihydroergocryptine (DHEC) in the rat.
PubMed·1980· 1 cited
Effect of repeated oral administration of phenobarbitone or DDT on hepatic glutathione S-transferase activity in non-human primates: Comparison with the rat
Biochemical Pharmacology·1979· 7 cited
Hepatic effects of xylidine isomers in rats
Toxicology·1979· 17 cited
The effect of DDT on hepatic microsomal drug-metabolising enzymes in the baboon: Comparison with the rat
Bulletin of Environmental Contamination and Toxicology·1978· 6 cited
Effect of repeated oral administration of isosorbide dinitrate on hepatic glutathione S-transferase activity in the rat
Biochemical Pharmacology·1978· 13 cited
Renal and bone uptake of tartaric acid in rats: Comparison of L(+) and DL-forms
Toxicology·1977· 7 cited
Percutaneous absorption of the 21-β-benzoylamino iso-butyrate of triamcinolone acetonide by rats and rabbits
Toxicology Letters·1977· 7 cited
Absorption and biotransformation of L(+)-tartaric acid in rats
Cellular and Molecular Life Sciences·1977· 11 cited
LIST OF PARTICIPANTS
Elsevier eBooks·1977
SPECIES DIFFERENCES IN DRUG METABOLISM; IN VIVO PARAMETERS OF HEPATIC DRUG-METABOLISING ENZYME ACTIVITY IN THE BABOON
Elsevier eBooks·1977
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Frequent Co-authors

L. F. Chasseaud(23), R.M. Sacharin(5), D. R. Hawkins(5), R.K. Grundy(3), Stephen A. Ballard(3), David Kirkpatrick(3), A. Darragh(2), S. A. Ballard(2), Göran Magnusson(1), Saima Majeed(1), W. Jorgeson(1), John O. Hunter(1), W R Burnham(1), A.R. Waller(1), R. Bonn(1), Tim Taylor(1), R. Girkin(1), E. Doyle(1), T. Taylor(1), R.K. Medd(1)