Jikui Guan

University of Gothenburg — Sweden

Medicine · Health Sciences

19h-index1.1kcitations46works0.52yr avg
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Research Topics

Neuroblastoma Research and Treatments(33), Cancer, Hypoxia, and Metabolism(14), Cancer therapeutics and mechanisms(11), Sperm and Testicular Function(6), Neuroendocrine Tumor Research Advances(6)

Publications46 total

ALK/ATR combination therapy is effective in neuroblastoma mouse tumors driven by MYCN
2025· 1 citedOpen Access
AlkTango reveals a role for Jeb/Alk signaling in the Drosophila heart
Cell Communication and Signaling·2025Open Access
Abstract B002: ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
Cancer Research·2024
ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to crizotinib
Frontiers in Oncology·2024· 1 citedOpen Access
ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
Proceedings of the National Academy of Sciences·2023· 22 citedOpen Access
Abstract C159: ALK signaling primes the DNA damage response allowing exploitation of ATR inhibition in ALK-driven Neuroblastoma
Molecular Cancer Therapeutics·2023
ALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
2023· 1 citedOpen Access
IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway
Cancers·2023· 19 citedOpen Access
Integrating scRNA and bulk-RNA sequencing develops a cell senescence signature for analyzing tumor heterogeneity in clear cell renal cell carcinoma
Frontiers in Immunology·2023· 11 citedOpen Access
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation
JCO Precision Oncology·2022· 16 citedOpen Access
Chromosome Imbalances in Neuroblastoma—Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future
Cancers·2021· 28 citedOpen Access
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling
Journal of Molecular Biology·2021· 10 citedOpen Access
BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells
Journal of Molecular Biology·2021· 13 citedOpen Access
Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration
Cell Reports·2021· 16 citedOpen Access
Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells
Cancers·2021· 14 citedOpen Access
ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of <i>ALK</i> mutation
The EMBO Journal·2021· 62 citedOpen Access
Abstract A36: Targeting anaplastic lymphoma kinase in neuroblastoma
Cancer Research·2020
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
Annals of Oncology·2019· 1 citedOpen Access
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways
Science Signaling·2018· 39 citedOpen Access
Abstract B27: Anaplastic lymphoma kinase addicted neuroblastoma cell lines are associated with growth upon treatment with MEK inhibitor trametinib
Cancer Research·2018
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Frequent Co-authors

Ruth H. Palmer(35), Bengt Hallberg(30), Ganesh Umapathy(19), Joachim T. Siaw(10), Jimmy Van den Eynden(9), Marcus Borenäs(8), Kathrin Pfeifer(7), Tommy Martinsson(7), Dan E. Lind(7), Patricia Mendoza-García(6), Wei‐Yun Lai(6), Diana Cervantes-Madrid(6), Georg Wolfstetter(5), Damini Chand(5), Kristina Ruuth(5), Dan Gustafsson(5), Susanne Fransson(4), Joel Johansson(4), Eva Jennische(4), Jonatan L. Gabre(4)