Isabel Ramis

Almirall (Spain) — Spain

Medicine · Health Sciences

23h-index1.5kcitations61works0.02yr avg
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Research Topics

Asthma and respiratory diseases(19), Inflammatory mediators and NSAID effects(10), Cytokine Signaling Pathways and Interactions(7), Analytical Chemistry and Chromatography(6), Drug-Induced Adverse Reactions(6)

Publications60 total

The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro
Scientific Reports·2022· 25 citedOpen Access
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
Journal of Medicinal Chemistry·2019· 31 citedOpen Access
Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats
Journal of Pharmacology and Experimental Therapeutics·2019· 32 cited
PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge
Biomarker Research·2018· 29 citedOpen Access
Tofacitinib ameliorates inflammation in a rat model of airway neutrophilia induced by inhaled LPS
Pulmonary Pharmacology & Therapeutics·2017· 20 cited
Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
Respiratory Research·2016· 41 citedOpen Access
Additional file 5: Table S3. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
Figshare·2016Open Access
A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response
Pharmacological Research·2015· 25 cited
New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats
2014· 1 cited
In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
2014· 2 cited
Targeting PI3Kδ or JAK in T-cells from COPD and severe asthma subjects reduces corticosteroid insensitive inflammatory responses
2013
Strategies to improve lung absorption of intratracheally administered compounds in Drug Discovery
Journal of Inflammation·2013Open Access
Highly potent aminopyridines as Syk kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 20 citedOpen Access
Pyrazine-based Syk kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 17 citedOpen Access
Characterization of a model of tracheal plasma extravasation in passively sensitized rats using anti-allergic and anti-inflammatory drugs by oral and intratracheal route
Pulmonary Pharmacology & Therapeutics·2011· 4 cited
The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis
Journal of Pharmacological Sciences·2009· 6 citedOpen Access
UR-1505, a salicylate able to selectively block T-cell activation, shows intestinal anti-inflammatory activity in the chronic phase of the DSS model of rat colitis
Inflammatory Bowel Diseases·2008· 10 citedOpen Access
The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition
Biochemical Pharmacology·2007· 15 cited
UR-1505, a New Salicylate, Blocks T Cell Activation through Nuclear Factor of Activated T Cells
Molecular Pharmacology·2007· 20 cited
Inflammatory markers in bronchoalveolar lavage fluid from human volunteers 2 hours after hydrogen fluoride exposure
Human & Experimental Toxicology·2005· 8 cited
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Frequent Co-authors

Joan Roselló‐Catafau(14), Ellen Gelpí(13), O. Bulbena(11), Montserrat Miralpeix(11), César Picado(10), J Roselló(8), Cristina Carreño(8), Georgina Hotter(7), Emilio Gelpı́(7), G. Bioque(7), Mónica Maldonado(6), Manuel Merlos(6), R. Lauwerys(5), E. Gelpı́(5), Adelina Orellana(5), Neus Prats(5), Júlio Gálvez(5), Antonio Zarzuelo(5), Antonio Mutti(4), J. Roselló(4)