Lawrence H. Cohen

Takeda (United States) — United States

Psychology · Social Sciences

41h-index6.0kcitations122works2.12yr avg
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Research Topics

Psychotherapy Techniques and Applications(19), Child and Adolescent Psychosocial and Emotional Development(17), Mental Health Research Topics(15), Psychological Well-being and Life Satisfaction(13), Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes(9)

Publications122 total

Comprehensive <i>in vitro</i> assessment of drug-drug interactions of the major human metabolite of soticlestat
Xenobiotica·2025· 2 citedOpen Access
In vitro mechanistic investigation of unusual clinical drug-drug interaction of trazpiroben on a major reductive metabolite upon rifampin co-administration
Drug Metabolism and Pharmacokinetics·2025
Addressing the challenges of determining fraction metabolized for low turnover drugs – An update from the quantitative fraction metabolized working group of the IQ consortium
Drug Metabolism and Pharmacokinetics·2025
Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions of Soticlestat as a Victim of CYP Induction and Inhibition, and as a Perpetrator of CYP and P–Glycoprotein Inhibition
Clinical Pharmacology in Drug Development·2025· 2 citedOpen Access
Longitudinal imaging of therapeutic enzyme expression after gene therapy for Fabry disease using positron emission tomography and the radiotracer [18F]AGAL
Molecular Therapy·2024· 5 citedOpen Access
Metabolism and Excretion of [14C]Mobocertinib, a Selective Covalent Inhibitor of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations, in Healthy Male Subjects
Drug Metabolism and Disposition·2024· 4 citedOpen Access
Physiologically-based Pharmacokinetic Modeling to Predict Drug–drug Interactions of Soticlestat (S29.001)
Neurology·2024
Soticlestat in Vitro Metabolism and Drug-drug Interactions: Comprehensive Investigations Display Minimal Notable Interactions (P9-1.012)
Neurology·2024· 4 cited
Radiosynthesis and Early Evaluation of a Positron Emission Tomography Imaging Probe [18F]AGAL Targeting Alpha-Galactosidase A Enzyme for Fabry Disease
Molecules·2023· 2 citedOpen Access
Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Drug Metabolism and Disposition·2022· 3 citedOpen Access
Metabolism and Disposition of [14C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors
Drug Metabolism and Disposition·2022· 5 citedOpen Access
Design of proteasome inhibitors with oral efficacy in vivo against <i>Plasmodium falciparum</i> and selectivity over the human proteasome
Proceedings of the National Academy of Sciences·2021· 35 citedOpen Access
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors
Drug Metabolism and Disposition·2020· 16 citedOpen Access
Metabolism of pevonedistat in patients with advanced solid tumors after intravenous infusion of [14C] pevonedistat
Drug Metabolism and Pharmacokinetics·2019
Family Issues in Pediatric Psychology: An Overview
2013· 7 cited
Interpersonal Competence and Daily Stress Generation in Individuals with Avoidant Personality Disorder Symptoms
Journal of Social and Clinical Psychology·2013· 15 cited
Social constraints on disclosure predict daily well-being in couples coping with early-stage breast cancer.
Journal of Family Psychology·2012· 73 cited
Reports of Stress-Related Growth From Daily Negative Events
Journal of Social and Clinical Psychology·2011· 47 cited
Daily support in couples coping with early stage breast cancer: Maintaining intimacy during adversity.
Health Psychology·2011· 111 cited
Abstract 4508: Nonclinical pharmacokinetics of TAK-441, a hedgehog pathway inhibitor
Cancer Research·2011· 1 cited
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Frequent Co-authors

Kathleen C. Gunthert(11), Crystal L. Park(5), Andrew C. Butler(5), Stephen Armeli(4), Lynn C. Towbes(4), Suzanne C. O’Neill(4), Laura H. Tolpin(4), Jean‐Philippe Laurenceau(4), Kimberly B. Dasch(4), Brendt P. Parrish(4), Tanya R. Hettler(4), Jeffrey P. Bjorck(3), Judith S. Beck(3), Lisa Herb(2), Elizabeth M. Swearingen(2), Charles E. Burt(2), Kathy Glyshaw(2), Patricia E. Roos(2), Amber Belcher(2), Elana Graber(2)