Jacobus Burggraaf

Leiden University Medical Center — Netherlands

Engineering · Physical Sciences

54h-index9.7kcitations354works5.32yr avg
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Research Topics

Nanoplatforms for cancer theranostics(36), Cancer Research and Treatments(28), Growth Hormone and Insulin-like Growth Factors(17), Cardiac electrophysiology and arrhythmias(13), Antibiotics Pharmacokinetics and Efficacy(13)

Publications352 total

Standardizing clinical trials in near-infrared fluorescence imaging: a workflow and regulatory framework proposal
npj Imaging·2026Open Access
Pharmacokinetics, safety, tolerability and fluorescence imaging of nizaracianine triflutate administered in three divided doses to healthy volunteers
British Journal of Clinical Pharmacology·2026Open Access
Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates
Frontiers in Pharmacology·2026Open Access
Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience
British Journal of Clinical Pharmacology·2025· 1 citedOpen Access
Preoperative chemotherapy reduces the accumulation of indocyanine green around colorectal liver metastases for use in fluorescence-guided surgery
Surgical Endoscopy·2025· 2 citedOpen Access
Correction: Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
EJNMMI Research·2025Open Access
Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model
Clinical Pharmacology & Therapeutics·2025· 1 citedOpen Access
Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
EJNMMI Research·2025· 1 citedOpen Access
Long-term Local Control Following CEA-targeted Fluorescence-guided Surgery in Patients With Locally Advanced and Recurrent Rectal Cancer
Molecular Imaging and Biology·2025· 1 citedOpen Access
Cardiac inotropy and cardiac calcium sensitization of PanLN800(-Forte), a cationic heptamethine indocyanine fluorescent contrast agent for intraoperative pan lymph node imaging
Toxicology and Applied Pharmacology·2024Open Access
Optical navigation using tumour-targeted near-infrared (NIR) fluorescence in pancreatic surgery: a phase II feasibility trial of a novel integrin-targeting fluorescent probe cRGD-ZW800-1
European Journal of Surgical Oncology·2024
Effects of Neoadjuvant Therapy on Tumour Target Expression of Oesophageal Cancer Tissue for NIR Fluorescence Imaging
Molecular Imaging and Biology·2024· 2 citedOpen Access
Selecting Targets for Molecular Imaging of Gastric Cancer: An Immunohistochemical Evaluation
Molecular Diagnosis & Therapy·2024· 6 citedOpen Access
Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent
Pharmacological Research·2024· 1 citedOpen Access
Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients
Molecular Imaging and Biology·2024· 8 citedOpen Access
Open-Label Interventional Study in Healthy Volunteers to Evaluate NO-Mediated Vasodilation by Dermal Allyl Isothiocyanate Challenge and Whole-Body Heat Stress
Journal of Experimental Pharmacology·2024· 1 citedOpen Access
Indocyanine green near-infrared fluorescence bowel perfusion assessment to prevent anastomotic leakage in minimally invasive colorectal surgery (AVOID): a multicentre, randomised, controlled, phase 3 trial
˜The œLancet. Gastroenterology & hepatology·2024· 61 citedOpen Access
A suction blister model to characterize epidermal wound healing and evaluate the efficacy of the topical wound healing agent INM-755 in healthy volunteers
European Journal of Pharmaceutical Sciences·2024· 1 citedOpen Access
Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T‐cell proliferation but residual T‐cell activity during maintenance immunosuppressive treatment
Clinical and Translational Science·2024· 4 citedOpen Access
Safety, reactogenicity and immunogenicity of an intranasal seasonal influenza vaccine adjuvanted with gram-positive matrix (GEM) particles (FluGEM): A randomized, double-blind, controlled, ascending dose study in healthy adults and elderly
Vaccine·2024· 8 citedOpen Access
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Frequent Co-authors

Adam F. Cohen(17), Alexander L. Vahrmeijer(13), Rik C. Schoemaker(8), Matthijs Moerland(7), Charlotte E.S. Hoogstins(6), Leonora S. F. Boogerd(6), Hanno Pijl(6), Kim S. de Valk(6), R.P. Meijer(6), J. Sven D. Mieog(5), Marieke L. de Kam(5), Henricus J.M. Handgraaf(5), Denise E. Hilling(5), Fabian A. Holman(5), Koen Peeters(5), Marion M. Deken(5), Ingrid M. C. Kamerling(4), Dennis P. Schaap(4), Miranda Kusters(4), Bérénice Framery(4)