Matthew L. Hillwig

University of Pittsburgh — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.8kcitations41works0.02yr avg
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Research Topics

Plant biochemistry and biosynthesis(19), Microbial Natural Products and Biosynthesis(15), Natural product bioactivities and synthesis(8), Alkaloids: synthesis and pharmacology(8), Natural Compound Pharmacology Studies(6)

Publications41 total

Molecular Insight into the Mg<sup>2+</sup>‐Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1
Angewandte Chemie·2018· 1 cited
Molecular Insight into the Mg<sup>2+</sup>‐Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1
Angewandte Chemie International Edition·2018· 19 cited
Probing Labdane-Related Diterpenoid Biosynthesis in the Fungal Genus <i>Aspergillus</i>
Journal of Natural Products·2017· 26 citedOpen Access
Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5
Nature Chemical Biology·2016· 174 citedOpen Access
Rücktitelbild: Discovery of a Promiscuous Non‐Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late‐Stage Halogenation of Aliphatic Carbons in Small Molecules (Angew. Chem. 19/2016)
Angewandte Chemie·2016Open Access
Back Cover: Discovery of a Promiscuous Non‐Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late‐Stage Halogenation of Aliphatic Carbons in Small Molecules (Angew. Chem. Int. Ed. 19/2016)
Angewandte Chemie International Edition·2016Open Access
Discovery of a Promiscuous Non‐Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late‐Stage Halogenation of Aliphatic Carbons in Small Molecules
Angewandte Chemie·2016· 22 cited
Discovery of a Promiscuous Non‐Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late‐Stage Halogenation of Aliphatic Carbons in Small Molecules
Angewandte Chemie International Edition·2016· 73 cited
Inside Cover: Aliphatic Halogenase Enables Late‐Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity (ChemBioChem 6/2016)
ChemBioChem·2016Open Access
Probing the promiscuity of <i>ent</i> -kaurene oxidases via combinatorial biosynthesis
Proceedings of the National Academy of Sciences·2016· 59 citedOpen Access
Aliphatic Halogenase Enables Late‐Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity
ChemBioChem·2016· 30 cited
Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase
Chemical Communications·2015· 38 citedOpen Access
Minimum Information about a Biosynthetic Gene cluster
Nature Chemical Biology·2015· 869 citedOpen Access
Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids
Chemical Science·2015· 21 citedOpen Access
Efficient heterocyclisation by (di)terpene synthases
Chemical Communications·2015· 42 citedOpen Access
A new family of iron-dependent halogenases acts on freestanding substrates
Nature Chemical Biology·2014· 162 cited
Characterization of an Orphan Diterpenoid Biosynthetic Operon from <i>Salinispora arenicola</i>
Journal of Natural Products·2014· 33 citedOpen Access
Inside Cover: Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean Cyanobacterium <i>Hapalosiphon welwitschii</i> (ChemBioChem 5/2014)
ChemBioChem·2014
Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean Cyanobacterium <i>Hapalosiphon welwitschii</i>
ChemBioChem·2014· 99 citedOpen Access
Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
BMC Genomics·2014· 195 citedOpen Access
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Frequent Co-authors

Reuben J. Peters(19), Xinyu Liu(15), Qin Zhu(9), Kuljira Ittiamornkul(7), Meimei Xu(5), Yisheng Wu(5), Kimberly Hammer(5), Eve Syrkin Wurtele(5), Diane F. Birt(5), Luqi Huang(4), Qiang Wang(4), Wei Gao(3), Guanghong Cui(3), Patricia A. Murphy(3), Mollie S. Tiernan(3), Sibongile Mafu(3), Francis M. Mann(3), Ye Shen(2), Heather A. Fuhrman(2), Tyler J. Sevco(2)