Denny Liggitt

University of Washington — United States

Immunology and Microbiology · Life Sciences

52h-index12.7kcitations142works0.52yr avg
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Research Topics

Immune Cell Function and Interaction(24), Virus-based gene therapy research(22), T-cell and B-cell Immunology(19), Immunotherapy and Immune Responses(19), RNA Interference and Gene Delivery(19)

Publications142 total

Reduced Function of the Adaptor SH2B3 Promotes T1D via Altered Cytokine-Regulated, T-Cell–Intrinsic Immune Tolerance
Diabetes·2025· 1 cited
<b>Reduced function of the adaptor SH2B3 promotes T1D via altered cytokine-regulated, T cell intrinsic immune tolerance</b>
2025Open Access
<b>Reduced function of the adaptor SH2B3 promotes T1D via altered cytokine-regulated, T cell intrinsic immune tolerance</b>
2025Open Access
Reduced function of the adaptor SH2B3 promotes T1D via altered gc cytokine-regulated, T cell intrinsic immune tolerance
2024· 1 citedOpen Access
Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome
Science Translational Medicine·2023· 24 cited
Supplemental Figures S1-S7; Supplemental Materials and Methods; and Supplemental Table S1 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Data from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Supplemental Figures S1-S7; Supplemental Materials and Methods; and Supplemental Table S1 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Movie S1 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Movie S2 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Movie S2 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Data from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
Movie S1 from ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme
2023Open Access
203 Insights into lupus biology from inborn errors of immunity: immunopathogenesis of STAT1 gain-of- function autoimmunity
2022Open Access
B Cells Drive MHC Class I–Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity
The Journal of Immunology·2022· 3 citedOpen Access
Pancreatic islet-specific engineered T <sub>regs</sub> exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
Science Translational Medicine·2022· 68 cited
Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell Dysfunction
The Journal of Immunology·2022· 11 citedOpen Access
The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis
The Journal of Immunology·2021· 13 citedOpen Access
Book Review: Pioneer Science and the Great Plagues: How Microbes, War, and Public Health Shaped Animal Health
Veterinary Pathology·2021
The actin-regulatory protein Hem-1 is essential for alveolar macrophage development
The Journal of Experimental Medicine·2021· 17 citedOpen Access
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Frequent Co-authors

David J. Rawlings(7), Robert J. Debs(6), Socheath Khim(5), Joan Goverman(4), Shaun W. Jackson(4), Blythe Sather(3), Christopher J. Kemp(3), Kay E. Gurley(3), Jane H. Buckner(3), Steven Dow(3), Hamed Arami(2), Kannan M. Krishnan(2), Alexander Y. Rudensky(2), Eric S. Huseby(2), Blair R. Renshaw(2), Barry L. Davison(2), Nora Sarvetnick(2), Timothy A. Stewart(2), Akhilesh K. Singh(2), Mohamed Oukka(2)