Scott P. Henry

Ionis Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index5.5kcitations149works4.02yr avg
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Research Topics

RNA Interference and Gene Delivery(43), DNA and Nucleic Acid Chemistry(40), Advanced biosensing and bioanalysis techniques(32), Complement system in diseases(12), Immune Response and Inflammation(11)

Publications148 total

Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system
Nucleic Acids Research·2025· 1 citedOpen Access
Antisense oligonucleotide jacifusen for FUS-ALS: an investigator-initiated, multicentre, open-label case series
The Lancet·2025· 20 citedOpen Access
Nonclinical Safety Assessment
Toxicologic Pathology·2025
Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model
The Journal of Immunology·2025Open Access
Reversable Acute Sedation Response of Phosphorothioate Antisense Oligonucleotides Following Local Delivery to the Central Nervous System
2025· 4 citedOpen Access
Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid
2025· 3 citedOpen Access
Assessing Hybridization-Dependent Off-Target Risk for Therapeutic Oligonucleotides: Updated Industry Recommendations
Nucleic Acid Therapeutics·2025· 13 citedOpen Access
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen
Immunobiology·2025· 8 citedOpen Access
A Combined Fertility and Developmental Toxicity Study with an Antisense Oligonucleotide Targeting Murine Apolipoprotein C-III mRNA in Mice
Nucleic Acid Therapeutics·2024· 1 cited
Carcinogenicity assessment of inotersen in Tg.rasH2 mice and Sprague-Dawley rats: Implications for 2′-MOE antisense oligonucleotides
Regulatory Toxicology and Pharmacology·2024Open Access
CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways
Journal of Thrombosis and Haemostasis·2024· 2 citedOpen Access
Contributors
Elsevier eBooks·2024
Overview of the Nonclinical Development Strategies and Class Effects of Oligonucleotide-based Therapeutics
Elsevier eBooks·2024
Complement C3d/C4d Deposition on Platelets Correlates with 2′-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys
Nucleic Acid Therapeutics·2023· 4 cited
Correlations between preclinical <scp>BJAB</scp> assay ranking of antisense drugs and clinical trial adverse events
Clinical and Translational Science·2023· 6 citedOpen Access
Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells
Nucleic Acid Therapeutics·2022· 16 cited
Assessment of the Immunogenicity Potential for Oligonucleotide-Based Drugs
Nucleic Acid Therapeutics·2022· 18 cited
Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells
Nucleic Acid Therapeutics·2022· 17 cited
Population pharmacokinetic/pharmacodynamic modelling of eplontersen, an antisense oligonucleotide in development for transthyretin amyloidosis
British Journal of Clinical Pharmacology·2022· 23 citedOpen Access
Assessment of the Effect of Organ Impairment on the Pharmacokinetics of 2′‐MOE and Phosphorothioate Modified Antisense Oligonucleotides
The Journal of Clinical Pharmacology·2022· 4 cited
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Frequent Co-authors

Arthur A. Levin(15), Richard S. Geary(13), Rosie Z. Yu(10), Douglas J. Kornbrust(8), David Monteith(6), Thomas A. Zanardi(6), Daniel A. Norris(5), Sebastien A. Burel(5), Husam S. Younis(5), Punit P. Seth(5), Eric E. Swayze(5), Yanfeng Wang(5), C. Frank Bennett(4), Patricia C. Giclas(4), Thazha P. Prakash(4), Janet M. Leeds(4), Noah Post(4), Colby S. Shemesh(4), Hans Gaus(3), Carol S. Auletta(3)