Ronald J. Lukas

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index9.3kcitations198works2.02yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(173), Receptor Mechanisms and Signaling(91), Ion channel regulation and function(78), Neuroscience and Neuropharmacology Research(29), Cholinesterase and Neurodegenerative Diseases(27)

Publications198 total

Neuroprotective amyloid β N‐terminal peptides differentially alter human α7‐ and α7β2‐nicotinic acetylcholine (nACh) receptor single‐channel properties
British Journal of Pharmacology·2024· 2 citedOpen Access
Neuroprotective amyloid-beta N-terminal peptides differentially alter human α7- and α7β2-nicotinic acetylcholine receptor single-channel properties
2023
Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells
Acta Pharmacologica Sinica·2021· 10 citedOpen Access
Sleep-related hypermotor epilepsy associated mutations uncover important kinetic roles of α4β2- nicotinic acetylcholine receptor intracellular structures
PLoS ONE·2021· 4 citedOpen Access
Implications of Oligomeric Amyloid-Beta (oAβ<sub>42</sub>) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline
Journal of Neuroscience·2020· 43 citedOpen Access
Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis
Biomolecules·2019· 22 citedOpen Access
Cocaine potently blocks neuronal α3β4 nicotinic acetylcholine receptors in SH-SY5Y cells
Acta Pharmacologica Sinica·2019· 10 citedOpen Access
Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms
PLoS ONE·2019· 27 citedOpen Access
Alpha6-containing nicotinic acetylcholine receptor is a highly sensitive target of alcohol
Neuropharmacology·2019· 28 citedOpen Access
Roles of Nicotine in the Development of Intracranial Aneurysm Rupture
Stroke·2018· 67 citedOpen Access
α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor
ACS Chemical Biology·2018· 9 citedOpen Access
Pharmacological and functional comparisons of α6/α3β2β3-nAChRs and α4β2-nAChRs heterologously expressed in the human epithelial SH-EP1 cell line
Acta Pharmacologica Sinica·2018· 12 citedOpen Access
Alcohol is a Positive Allosteric Modulator on Alpha6-Containing Nicotinic Acetylcholine Receptors
SSRN Electronic Journal·2018Open Access
Distinctive Roles for α7*- and α9*-Nicotinic Acetylcholine Receptors in Inflammatory and Autoimmune Responses in the Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
Frontiers in Cellular Neuroscience·2017· 28 citedOpen Access
Isoform‐specific mechanisms of a3b4*‐nicotinic acetylcholine receptor modulation by the prototoxin lynx1
The FASEB Journal·2017· 64 citedOpen Access
Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists
European Journal of Medicinal Chemistry·2016· 14 citedOpen Access
Emamectin is a non-selective allosteric activator of nicotinic acetylcholine receptors and GABA A/C receptors
Biochemical and Biophysical Research Communications·2016· 15 citedOpen Access
Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III
ACS Chemical Neuroscience·2016· 9 cited
Differential α4(+)/(−)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms
Journal of Biological Chemistry·2015· 43 citedOpen Access
Distinctive effects of nicotinic receptor intracellular-loop mutations associated with nocturnal frontal lobe epilepsy
Neuropharmacology·2015· 27 citedOpen Access
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Frequent Co-authors

Jie Wu(14), Andrew A. George(7), Paul Whiteaker(6), J. Brek Eaton(5), Linda Lucero(5), Yen‐Ping Kuo(4), Maryka Quik(3), Daniel Bertrand(3), Jon Lindstrom(3), John Denis Fryer(3), F. Ivy Carroll(3), Hernán A. Navarro(3), Bruce E. Blough(3), Alain R. Simard(3), Merouane Bencherif(3), Fu‐Dong Shi(3), Jian‐Hong Peng(3), Katherine Schroeder(3), Jun Hu(3), Kechun Yang(3)