Srilatha Simhadri

Rutgers, The State University of New Jersey — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index632citations28works3.02yr avg
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Research Topics

DNA Repair Mechanisms(17), CRISPR and Genetic Engineering(13), Genetics, Aging, and Longevity in Model Organisms(7), BRCA gene mutations in cancer(7), PARP inhibition in cancer therapy(3)

Publications28 total

Evolution of Rapid Clonal Dynamics and Non–Cross-Resistance in Response to Alternating Targeted Therapy and Chemotherapy in BRAF-V600E-Mutant Colon Cancer
JCO Precision Oncology·2024· 3 citedOpen Access
Data from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Methods from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Figures from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Data from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Methods from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Table from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Figures from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
Supplementary Table from ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G<sub>2</sub>–M Checkpoint Maintenance
2023Open Access
ATR/ATM-Mediated Phosphorylation of BRCA1 T1394 Promotes Homologous Recombinational Repair and G2–M Checkpoint Maintenance
Cancer Research·2021· 26 citedOpen Access
PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response
Oncogene·2018· 53 citedOpen Access
Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1–PALB2 Interaction
Cancer Research·2018· 15 cited
Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage
Scientific Reports·2017· 34 citedOpen Access
Abstract 2470: Compromised BRCA1-PALB2 interaction is associated with breast cancer risk
Cancer Research·2017
Abstract 4129: Novel oncogenic BRAF fusions and impact on targeted therapies
Cancer Research·2017
Abstract 2487: Functional characterization of the BRCA2 variant, K3326X
Cancer Research·2017
<i>BRAF</i> Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in <i>BRAF</i>V600E Mutant Melanoma
Clinical Cancer Research·2017· 61 cited
Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
eLife·2017· 104 citedOpen Access
Author response: Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance
2017· 1 citedOpen Access
Compromised BRCA1–PALB2 interaction is associated with breast cancer risk
Oncogene·2017· 89 citedOpen Access
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Frequent Co-authors

Bing Xia(20), Tzeh Keong Foo(14), Yanying Huo(13), Samuel F. Bunting(11), Gabriele Vincelli(11), Shridar Ganesan(10), Eric Huselid(9), Joonyoung Her(9), Hong Li(9), Weixing Zhao(9), Haiyan Zheng(8), Xiaochun Yu(8), Meiling Wang(7), Atul Kulkarni(5), Tao Li(5), Tao Li(4), Rachel William Anantha(3), Hong Cai(3), Kim M. Hirshfield(3), Andrew G. Cole(3)