Scott B. Ficarro

Harvard University — United States

Chemistry · Physical Sciences

67h-index16.2kcitations236works5.62yr avg
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Research Topics

Advanced Proteomics Techniques and Applications(31), Mass Spectrometry Techniques and Applications(30), Protein Degradation and Inhibitors(29), Lung Cancer Treatments and Mutations(23), Ubiquitin and proteasome pathways(23)

Publications236 total

Proteasome Cap Targeting Chimeras for Ubiquitination‐Independent Targeted Protein Degradation
Angewandte Chemie·2026
Proteasome Cap Targeting Chimeras for Ubiquitination‐Independent Targeted Protein Degradation
Angewandte Chemie International Edition·2026
CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity
JCI Insight·2025Open Access
Overcoming EGFR resistance by monovalent and bident inhibitors targeting Cys775
2025Open Access
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
Science·2025· 1 citedOpen Access
1228 Immune escape through oncogene-mediated editing of the HLA-ligandome
Regular and Young Investigator Award Abstracts·2025Open Access
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors
UNC Libraries·2025Open Access
Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins
Nature Chemistry·2025· 6 citedOpen Access
Leveraging HILIC/ERLIC separations for online nanoscale LC-MS/MS analysis of phosphopeptide isoforms from RNA polymerase II C-terminal domain
Journal of Chromatography B·2025
A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation
Molecular Cell·2025· 8 cited
Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors
SLAS DISCOVERY·2024Open Access
Leveraging HILIC/ERLIC Separations for Online Nanoscale LC-MS/MS Analysis of Phosphopeptide Isoforms from RNA Polymerase II C-terminal Domain
2024· 1 citedOpen Access
Template-assisted covalent modification underlies activity of covalent molecular glues
Nature Chemical Biology·2024· 66 citedOpen Access
Abstract NG05: Epitope editing enables targeted immunotherapy of acute myeloid leukemia
Cancer Research·2024
Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes
Journal of Biological Chemistry·2024· 4 citedOpen Access
APIR: Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control
Genomics Proteomics & Bioinformatics·2024· 3 citedOpen Access
Bioorthogonally activated reactive species for target identification
Chem·2024· 6 citedOpen Access
Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality
ACS Central Science·2024· 12 citedOpen Access
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases
Journal of Medicinal Chemistry·2024· 4 citedOpen Access
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells
Nature Medicine·2024Open Access
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Frequent Co-authors

Jarrod A. Marto(34), Nathanael S. Gray(13), Tinghu Zhang(6), Eric C. Peters(6), Jeffrey Shabanowitz(5), Donald F. Hunt(5), Forest M. White(5), Taebo Sim(5), Michael J. Eck(5), Kenneth D. Westover(5), Pasi A. Jänne(4), Guillaume Adelmant(4), Ting Xie(4), Nicholas Kwiatkowski(3), Thomas Look(3), Kwok‐Kin Wong(3), Peter K. Sorger(3), Nelly Khidekel(3), Linda C. Hsieh‐Wilson(3), Sang Min Lim(3)