Nathalie Coulombe

National Research Council Canada — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index3.0kcitations26works3.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(8), Virus-based gene therapy research(7), Neuroscience and Neuropharmacology Research(4), Neuropeptides and Animal Physiology(4), Viral Infectious Diseases and Gene Expression in Insects(4)

Publications26 total

Optimization of adeno-associated viral (AAV) gene therapies vectors for balancing efficacy, longevity and safety for clinical application
Gene Therapy·2025· 5 cited
Acute intracardiac electrogram changes and their relation to pulsed field ablation dose in porcine left ventricle
EP Europace·2024· 1 citedOpen Access
Production, purification and immunogenicity of Gag virus-like particles carrying SARS-CoV-2 components
Vaccine·2023· 11 cited
Preclinical Development and Characterization of Novel Adeno-Associated Viral Vectors for the Treatment of Lipoprotein Lipase Deficiency
Human Gene Therapy·2023· 12 cited
Gene Editing/Gene Therapies: PRECLINICAL EXPLORATION OF NOVEL ROUTES OF ADMINISTRATION FOR AN ADENO-ASSOCIATED VIRUS-BASED GENE THERAPY FOR THE TREATMENT OF LIPOPROTEIN LIPASE DEFICIENCY
Cytotherapy·2023
Packaging cells for lentiviral vectors generated using the cumate and coumermycin gene induction systems and nanowell single-cell cloning
Molecular Therapy — Methods & Clinical Development·2023· 12 citedOpen Access
Rapid In-Process Monitoring of Lentiviral Vector Particles by High-Performance Liquid Chromatography
Molecular Therapy — Methods & Clinical Development·2020· 18 citedOpen Access
292. Towards Large-Scale Manufacturing of Adeno-Associated Virus by Transient Transfection of HEK293 Suspension Cells in a Stirred Tank Bioreactor Using Serum-Free Medium
Molecular Therapy·2016· 3 citedOpen Access
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses
Bioorganic & Medicinal Chemistry Letters·2013· 97 cited
Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin
Biological Chemistry·2010· 3 cited
Caspase-7 Expanded Function and Intrinsic Expression Level Underlies Strain-Specific Brain Phenotype of<i>Caspase-3</i>-Null Mice
Journal of Neuroscience·2004· 100 citedOpen Access
Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics
The Journal of Experimental Medicine·2004· 53 citedOpen Access
Characterization of the Human Cysteinyl Leukotriene 2 Receptor
Journal of Biological Chemistry·2000· 661 citedOpen Access
Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
PubMed·2000· 49 cited
Coexpression of Full-Length γ-Aminobutyric AcidB(GABAB) Receptors with Truncated Receptors and Metabotropic Glutamate Receptor 4 Supports the GABAB Heterodimer as the Functional Receptor
Journal of Pharmacology and Experimental Therapeutics·2000· 17 cited
Characterization of the human cysteinyl leukotriene CysLT1 receptor
Nature·1999· 968 cited
Discovery of a receptor related to the galanin receptors
FEBS Letters·1999· 498 cited
Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity
Journal of Biological Chemistry·1999· 212 citedOpen Access
Cloning of a Novel G-Protein-Coupled Receptor GPR 51 Resembling GABABReceptors Expressed Predominantly in Nervous Tissues and Mapped Proximal to the Hereditary Sensory Neuropathy Type 1 Locus on Chromosome 9
Genomics·1999· 22 cited
Discovery of a receptor related to the galanin receptors. FEBS Lett
1999· 20 cited
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Frequent Co-authors

Gary P. O’Neill(9), Anne Châteauneuf(6), Mark Abramovitz(5), Jilly F. Evans(5), Gordon Ng(5), Rénald Gilbert(5), Parminder S. Chahal(5), Kathleen M. Metters(4), Stacia Kargman(4), Brian F. O’Dowd(4), Tuan Nguyen(4), Susan R. George(4), Lee F. Kolakowski(4), Nasha Nassoury(4), Regina Cheng(3), Andrew D. Howard(3), Carina P. Tan(3), Nathalie Éthier(3), Terence E. Hébert(3), Richard Sullivan(3)