Charles G. Garlisi

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Medicine · Health Sciences

27h-index2.5kcitations58works2.72yr avg
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Research Topics

Asthma and respiratory diseases(13), Antibiotic Resistance in Bacteria(10), Immune Cell Function and Interaction(8), Chemokine receptors and signaling(7), Immune Response and Inflammation(6)

Publications58 total

Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
Bioorganic & Medicinal Chemistry Letters·2024· 2 cited
Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Journal of Medicinal Chemistry·2024· 6 citedOpen Access
Discovery of Sulfone Containing Metallo-B-Lactamase Inhibitors with Reduced Bacterial Cell Efflux and Histamine Release Issues
SSRN Electronic Journal·2024Open Access
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates
Journal of Medicinal Chemistry·2022· 23 citedOpen Access
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes
Bioorganic & Medicinal Chemistry Letters·2020· 16 citedOpen Access
Inhibitor of intramembrane protease RseP blocks the σ <sup>E</sup> response causing lethal accumulation of unfolded outer membrane proteins
Proceedings of the National Academy of Sciences·2018· 67 citedOpen Access
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma
ACS Medicinal Chemistry Letters·2018· 11 citedOpen Access
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of <i>Mycobacterium tuberculosis</i> Dihydrofolate Reductase
ACS Chemical Biology·2017· 28 citedOpen Access
The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh2 antagonists
Bioorganic & Medicinal Chemistry Letters·2017· 7 citedOpen Access
Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase
PLoS ONE·2017· 27 citedOpen Access
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor
Journal of Medicinal Chemistry·2017· 10 cited
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis
Bioorganic & Medicinal Chemistry Letters·2017· 13 citedOpen Access
Discovery of novel BTK inhibitors with carboxylic acids
Bioorganic & Medicinal Chemistry Letters·2016· 18 citedOpen Access
Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus
Bioorganic & Medicinal Chemistry Letters·2016· 12 cited
Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors
Bioorganic & Medicinal Chemistry Letters·2016· 17 citedOpen Access
Discovery of potent wall teichoic acid early stage inhibitors
Bioorganic & Medicinal Chemistry Letters·2016· 16 cited
<i>In Vitro</i> and <i>In Vivo</i> Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase
Antimicrobial Agents and Chemotherapy·2016· 22 citedOpen Access
TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci
Science Translational Medicine·2016· 108 cited
High-throughput screening of antibiotic-resistant bacteria in picodroplets
Lab on a Chip·2016· 118 cited
Discovery of 8-Amino-imidazo[1,5-<i>a</i>]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis
ACS Medicinal Chemistry Letters·2015· 38 citedOpen Access
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Frequent Co-authors

Shelby P. Umland(18), Kristine Devito(13), Robert W. Egan(13), Himanshu Shah(9), Yuntao Wan(9), Thierry Fischmann(8), Terry Roemer(8), Angela Falcone(8), M. Motasim Billah(8), Nicholas Murgolo(6), Paul A. Mann(6), Payal R. Sheth(6), Jing Su(6), Christopher M. Tan(6), Fang Tian(6), Deen Tulshian(6), James Jakway(6), Hongchen Qiu(6), Todd Mayhood(5), Ronald E. Painter(5)