Clara Brieke

Max Planck Institute for Medical Research — Germany

Medicine · Health Sciences

20h-index2.3kcitations31works0.02yr avg
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Research Topics

Microbial Natural Products and Biosynthesis(21), Chemical Synthesis and Analysis(16), Photochromic and Fluorescence Chemistry(7), Carbohydrate Chemistry and Synthesis(6), Photoreceptor and optogenetics research(5)

Publications31 total

Systematic risk identification and assessment using a new risk map in pharmaceutical R&D
Drug Discovery Today·2021· 14 cited
Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach
Journal of Inorganic Biochemistry·2018· 10 citedOpen Access
The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis
Nature Communications·2018· 20 citedOpen Access
A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis
Chemical Communications·2018· 27 citedOpen Access
Efficient cosubstrate enzyme pairs for sequence-specific methyltransferase-directed photolabile caging of DNA
Chemical Communications·2018· 28 citedOpen Access
The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones
ACS Chemical Biology·2017· 14 citedOpen Access
Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency
Biochemistry·2017· 26 cited
Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
Beilstein Journal of Organic Chemistry·2016· 14 citedOpen Access
F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE
Scientific Reports·2016· 38 citedOpen Access
3′-NADP and 3′-NAADP, Two Metabolites Formed by the Bacterial Type III Effector AvrRxo1
Journal of Biological Chemistry·2016· 21 citedOpen Access
More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH
Molecular BioSystems·2016· 24 cited
Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis
Journal of the American Chemical Society·2016· 56 cited
Facile Synthetic Access to Glycopeptide Antibiotic Precursor Peptides for the Investigation of Cytochrome P450 Action in Glycopeptide Antibiotic Biosynthesis
Methods in molecular biology·2016· 5 cited
Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates
Chemical Communications·2016· 13 cited
Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X‐Domain from Nonribosomal Peptide Biosynthesis
Angewandte Chemie International Edition·2015· 49 cited
Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X‐Domain from Nonribosomal Peptide Biosynthesis
Angewandte Chemie·2015· 11 cited
Azobenzene C‐Nucleosides for Photocontrolled Hybridization of DNA at Room Temperature
Chemistry - A European Journal·2015· 51 cited
Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis
MedChemComm·2015· 1 cited
X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
Nature·2015· 200 cited
Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products
Natural Product Reports·2015· 116 citedOpen Access
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Frequent Co-authors

Max J. Cryle(21), Madeleine Peschke(12), Kristina Haslinger(9), Alexander Heckel(6), Falk Rohrbach(3), Alexander Gottschalk(3), Roderich D. Süßmuth(3), Günter Mayer(2), Eglé Maximowitsch(2), Stefanie Uhlmann(2), Lina Sieverling(2), Thomas Goldau(2), Keiji Murayama(2), Hiroyuki Asanuma(2), Veronika Kratzig(2), Michael Heimes(2), Anja Greule(2), Veronika Ulrich(2), Andrea Rocker(2), Anton Meinhart(2)