Tohru Kozasa

Northeastern University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

54h-index11.5kcitations128works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(75), Receptor Mechanisms and Signaling(34), Ion channel regulation and function(20), Cell Adhesion Molecules Research(17), Cellular transport and secretion(13)

Publications127 total

Allosteric coupling between PIP <sub>2</sub> and Ca <sup>2+</sup> binding sites gates TMEM16A channels
Proceedings of the National Academy of Sciences·2026Open Access
BPS2026 - Structural basis of opposite regulation of heteromeric GIRK1/2 and homomeric GIRK2 channels by cholesterol
Biophysical Journal·2026
DATA: "Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels"
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
DATA: "Allosteric coupling between PIP2 and Ca2+ binding sites gates TMEM16A channels"
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Receptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides
Journal of Biological Chemistry·2024Open Access
Effect of manuka honey on human immunodeficiency virus type 1 reverse transcriptase activity
Natural Product Research·2021· 11 cited
Gα q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain
UNC Libraries·2020Open Access
Purification of Recombinant G Protein α and βγ Subunits from Sf9 Cells
2020· 2 cited
Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors
Pflügers Archiv - European Journal of Physiology·2018· 21 cited
Visualization of ligand‐induced G <sub>i</sub> ‐protein activation in chemotaxing cells
The FASEB Journal·2016· 3 cited
PDB Files S1 and S2
2015
Gα13/PDZ-RhoGEF/RhoA Signaling Is Essential for Gastrin-Releasing Peptide Receptor–Mediated Colon Cancer Cell Migration
Molecular Pharmacology·2014· 32 citedOpen Access
The 2.7‐Å crystal structure of Gα12 in complex with a regulator of G protein signaling homology (RH) domain (843.1)
The FASEB Journal·2014
Different Raf Protein Kinases Mediate Different Signaling Pathways to Stimulate E3 Ligase RFFL Gene Expression in Cell Migration Regulation
Journal of Biological Chemistry·2013· 18 citedOpen Access
G protein–dependent basal and evoked endothelial cell vWF secretion
Blood·2013· 26 citedOpen Access
A Computational Model Predicts That Gβγ Acts at a Cleft Between Channel Subunits to Activate GIRK1 Channels
Science Signaling·2013· 28 citedOpen Access
Modification of p115RhoGEF Ser330 regulates its RhoGEF activity
Cellular Signalling·2013· 4 citedOpen Access
Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex
Structure·2013· 65 citedOpen Access
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
Nature Cell Biology·2012· 154 citedOpen Access
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13
The Journal of Biochemistry·2011· 77 citedOpen Access
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Frequent Co-authors

Alfred G. Gilman(12), Paul C. Sternweis(6), T. Voyno-Yasenetskaya(6), Pamela M. Sternweis(5), Hiroshi Itoh(5), Y Kaziro(4), John H. Kehrl(4), Shihori Tanabe(4), Tetsuya Tsukamoto(3), John R. Hepler(3), Takeharu Kawano(3), J.J.G. Tesmer(3), Masao Matsuoka(3), N. Suzuki(3), Hyeseon Cho(3), Motohiro Nishida(3), Yoshiko Maruyama(3), Taku Nagao(3), Hitoshi Kurose(3), Rita Vaiškunaite(3)