Jay Shendure

University of Washington — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

167h-index121.4kcitations660works15.52yr avg
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Research Topics

Single-cell and spatial transcriptomics(110), Genomics and Chromatin Dynamics(95), RNA and protein synthesis mechanisms(88), CRISPR and Genetic Engineering(82), Genomics and Phylogenetic Studies(75)

Publications651 total

Development and implementation of an AI system for clinical toxicology sign-outs
2026Open Access
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording
Nature Biotechnology·2025· 2 citedOpen Access
Large-scale discovery of neural enhancers for cis-regulation therapies
2025· 1 citedOpen Access
Single-cell, multi-region profiling of the macaque brain across the lifespan
2025Open Access
Multiplex design and discovery of proximity handles for programmable proteome editing
2025· 1 citedOpen Access
Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning
2025Open Access
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks
Nature Genetics·2025· 1 citedOpen Access
Multicondition and multimodal temporal profile inference during mouse embryonic development
Genome Research·2025Open Access
Capture-C MPRA: A high-throughput method to simultaneously characterize promoter interactions and regulatory activity
2025· 2 citedOpen Access
Lineage recording in monoclonal gastruloids reveals heritable modes of early development
2025· 7 citedOpen Access
Barcoded monoclonal embryoids are a potential solution to confounding bottlenecks in mosaic organoid screens
2025· 4 citedOpen Access
An Improved, High-Yield Method for Isolating Nuclei from Individual Zebrafish Embryos for Single-Nucleus RNA Sequencing
Zebrafish·2025
CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation
BMC Biology·2025· 1 citedOpen Access
Cross-species imputation and comparison of single-cell transcriptomic profiles
Genome biology·2025· 6 citedOpen Access
A molecular proximity sensor based on an engineered, dual-component guide RNA
eLife·2025· 3 citedOpen Access
Author response: A molecular proximity sensor based on an engineered, dual-component guide RNA
2025Open Access
Combinatorial mapping of E3 ubiquitin ligases to their target substrates
Molecular Cell·2025· 14 citedOpen Access
Multiplex generation and single-cell analysis of structural variants in mammalian genomes
Science·2025· 14 citedOpen Access
P-2349. Clinical and genomic epidemiology of coxsackievirus A21 and enterovirus D68 in homeless shelters, King County, Washington, 2019-2021
Open Forum Infectious Diseases·2025Open Access
Technical and biological sources of noise confound multiplexed enhancer AAV screening
2025· 4 citedOpen Access
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Frequent Co-authors

Deborah A. Nickerson(10), Brian J. O’Roak(9), Cole Trapnell(9), Evan E. Eichler(9), Choli Lee(9), Riza M. Daza(9), Martin Kircher(7), Frank J. Steemers(7), Jacob O. Kitzman(7), Michael J. Bamshad(7), Andrew J. Hill(5), Emily H. Turner(5), Sarah Ng(5), Andrew C. Adey(5), Darren A. Cusanovich(5), Hannah A. Pliner(5), Gregory M. Cooper(4), Junyue Cao(4), Lena Christiansen(4), Laura Vives(4)