Edward C. Cooper

Baylor College of Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

38h-index7.3kcitations120works0.72yr avg
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Research Topics

Ion channel regulation and function(80), Neuroscience and Neuropharmacology Research(59), Cardiac electrophysiology and arrhythmias(34), Epilepsy research and treatment(19), Genetics and Neurodevelopmental Disorders(13)

Publications120 total

Early sodium channel blocker use improves seizures and neurodevelopment in <i>KCNQ2</i> -related disorders
2026Open Access
Molecular dynamics of the pathogenic <i>KCNQ2</i> variant G256W reveals mechanisms of channel dysfunction in epileptic encephalopathy
Journal of Biomolecular Structure and Dynamics·2026
Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathy
2025Open Access
Author response: Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
2025Open Access
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
eLife·2025· 2 citedOpen Access
P272: Does sponsored genetic testing for pediatric epilepsy expand access?
Genetics in Medicine Open·2025Open Access
Author response: Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
2024Open Access
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
2024· 2 citedOpen Access
Optimizing clinical interpretability of functional evidence in epilepsy-related ion channel variants
2024· 1 citedOpen Access
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
eLife·2024· 2 citedOpen Access
Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy
2024Open Access
Plural molecular and cellular mechanisms of pore domain <i>KCNQ2</i> encephalopathy
2024· 1 citedOpen Access
Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment
Neurotherapeutics·2023· 9 citedOpen Access
Phenotypic and functional assessment of two novel KCNQ2 gain-of-function variants Y141N and G239S and effects of amitriptyline treatment
Research Square (Research Square)·2023· 4 citedOpen Access
<i>KCNA1</i> gain‐of‐function epileptic encephalopathy treated with 4‐aminopyridine
Annals of Clinical and Translational Neurology·2023· 15 citedOpen Access
Genetic Variant in Nicotinic Receptor α4-Subunit Causes Sleep-Related Hyperkinetic Epilepsy via Increased Channel Opening
International Journal of Molecular Sciences·2022· 5 citedOpen Access
KCNQ2 R144 variants cause neurodevelopmental disability with language impairment and autistic features without neonatal seizures through a gain-of-function mechanism
EBioMedicine·2022· 42 citedOpen Access
Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine
Experimental Neurology·2022· 16 citedOpen Access
High-throughput evaluation of epilepsy-associated KCNQ2 variants reveals functional and pharmacological heterogeneity
JCI Insight·2022· 61 citedOpen Access
KCNQ channel PIP2 modulation: Two loose links, three rings, and a twist
Neuron·2022· 7 cited
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Frequent Co-authors

Lily Yeh Jan(7), Maurizio Taglialatela(6), Sarah Weckhuysen(6), Yuh Nung Jan(5), Nishtha Joshi(5), Ingrid E. Scheffer(4), Baouyen Tran(4), Francesco Miceli(4), Maria Virginia Soldovieri(4), David A. Greenberg(4), Vann Bennett(3), J Gordon Millichap(3), Daniel H. Lowenstein(3), Gaëtan Lesca(3), Mingxuan Xu(3), Celia L. Carpenter(3), Joseph G. Gleeson(2), Kristina M. Allen(2), Jeremy W. Fox(2), Samuel F. Berkovic(2)