Hakon Leffler

Lund University — Sweden

Immunology and Microbiology · Life Sciences

85h-index24.9kcitations369works4.32yr avg
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Research Topics

Galectins and Cancer Biology(249), Glycosylation and Glycoproteins Research(182), Signaling Pathways in Disease(74), Peptidase Inhibition and Analysis(67), Toxin Mechanisms and Immunotoxins(64)

Publications368 total

Synthesis of β-d-C-galactopyranosyl compounds including constrained derivatives from clickable building blocks and evaluation as ligands for galectins
European Journal of Medicinal Chemistry·2026Open Access
Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer
2026
Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate
Nature Communications·2025· 2 citedOpen Access
Author response for "Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition"
2025
Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors
Acta Pharmaceutica·2025Open Access
Author Correction: Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Communications Chemistry·2025· 1 citedOpen Access
Publisher Correction: Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis
Nature Cell Biology·2025· 2 citedOpen Access
Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
Communications Chemistry·2025· 3 citedOpen Access
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis
Nature Cell Biology·2025· 13 cited
Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition
RSC Chemical Biology·2025· 1 citedOpen Access
Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils
Frontiers in Immunology·2024· 4 citedOpen Access
Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer
Journal of Medicinal Chemistry·2024· 2 cited
Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
European Journal of Pharmacology·2024· 10 cited
Sulfonamide-derivatized galactosides selectively target an unexplored binding site in the galectin-9N-terminal domain
Bioorganic & Medicinal Chemistry·2024· 1 citedOpen Access
Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction
2024Open Access
Exploration into Galectin-3 Driven Endocytosis and Lattices
Biomolecules·2024· 8 citedOpen Access
The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis
Frontiers in Pharmacology·2024· 9 citedOpen Access
Galectin-8N-Selective 4-Halophenylphthalazinone-Galactals Double π-Stack in a Unique Pocket
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
Determining the Affinity and Kinetics of Small Molecule Inhibitors of Galectin-1 Using Surface Plasmon Resonance
International Journal of Molecular Sciences·2024· 1 citedOpen Access
Myocardin related transcription factor and galectin-3 drive lipid accumulation in human blood vessels
Vascular Pharmacology·2024
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Frequent Co-authors

Ulf J. Nilsson(12), S H Barondes(7), Michael A. Gitt(5), James M. Rini(5), Samuel H. Barondes(4), Richard D. Cummings(4), Alison C. MacKinnon(4), Tariq Sethi(4), Emma Salomonsson(4), Anna Karlsson(4), Susanne Carlsson(3), Tamara Delaine(3), Barbro Kahl‐Knutsson(3), Ulf Ryde(3), Mikael Akke(3), Hans Schambye(3), Douglas N.W. Cooper(2), Kurt Drickamer(2), Yuning Qian(2), Françoise Poirier(2)