R. Luke Wiseman

Scripps Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

52h-index10.2kcitations207works2.02yr avg
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Research Topics

Endoplasmic Reticulum Stress and Disease(104), Mitochondrial Function and Pathology(36), Autophagy in Disease and Therapy(32), Amyloidosis: Diagnosis, Treatment, Outcomes(30), Cellular transport and secretion(23)

Publications207 total

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
2025Open Access
Author response: Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
2025Open Access
Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
Improving Proteostasis of Trafficking-Deficient GABA <sub>A</sub> Receptor Variants by Activating IRE1
ACS Chemical Neuroscience·2025Open Access
Pharmacological targeting of RIG-I can selectively activate the integrated stress response
Science Advances·2025Open Access
eLife Assessment: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
2025Open Access
eLife Assessment: The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis
2025Open Access
eLife Assessment: Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
2025Open Access
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4
Immunity·2025· 6 citedOpen Access
eLife Assessment: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
2025Open Access
Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
ACS Chemical Biology·2025
Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity
eLife·2025Open Access
Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
2025Open Access
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
2025· 1 citedOpen Access
Inhibition of NF-κB Signaling by the Reactive Glycolytic Metabolite Methylglyoxal
2025Open Access
eLife Assessment: Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response
2025Open Access
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure
ACS Chemical Biology·2025· 1 citedOpen Access
Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity
2025Open Access
Author Correction: DELE1 oligomerization promotes integrated stress response activation
Nature Structural & Molecular Biology·2025
Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity
2025Open Access
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Frequent Co-authors

Jeffery W. Kelly(25), Evan T. Powers(16), Lars Plate(10), Joseph C. Genereux(7), Lisa M. Ryno(5), Ryan J Paxman(5), Gabriel C. Lander(5), Ian A. Wilson(4), Matthew D. Shoulders(4), Cristina Puchades(4), T. Kelly Rainbolt(4), Julia M. D. Grandjean(4), Per Hammarström(3), Yoshiki Sekijima(3), William E. Balch(3), Christina B. Cooley(3), Jaclyn M. Saunders(3), Aparajita Madhavan(3), Mia Shin(3), Ted R. Foss(3)