Brunella Taddeo

University of Chicago — United States

Medicine · Health Sciences

25h-index2.1kcitations38works0.02yr avg
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Research Topics

Herpesvirus Infections and Treatments(23), HIV Research and Treatment(10), Virus-based gene therapy research(10), RNA regulation and disease(8), HIV/AIDS drug development and treatment(7)

Publications38 total

Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage
Journal of Virology·2015· 22 citedOpen Access
The Nuclear-Cytoplasmic Shuttling of Virion Host Shutoff RNase Is Enabled by pU <sub>L</sub> 47 and an Embedded Nuclear Export Signal and Defines the Sites of Degradation of AU-Rich and Stable Cellular mRNAs
Journal of Virology·2013· 21 citedOpen Access
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the U <sub>L</sub> 47 tegument protein
Proceedings of the National Academy of Sciences·2013· 60 citedOpen Access
The Herpes Simplex Virus Host Shutoff RNase Degrades Cellular and Viral mRNAs Made before Infection but Not Viral mRNA Made after Infection
Journal of Virology·2013· 33 citedOpen Access
The Virion Host Shutoff RNase Plays a Key Role in Blocking the Activation of Protein Kinase R in Cells Infected with Herpes Simplex Virus 1
Journal of Virology·2013· 44 citedOpen Access
Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma
International Journal of Vascular Medicine·2011· 17 citedOpen Access
Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase
Journal of Virology·2010· 30 citedOpen Access
The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes
Proceedings of the National Academy of Sciences·2009· 15 citedOpen Access
The strategy of herpes simplex virus replication and takeover of the host cell
Cambridge University Press eBooks·2007· 25 cited
Replication-Competent Herpes Simplex Virus 1 Isolates Selected from Cells Transfected with a Bacterial Artificial Chromosome DNA Lacking Only the U <sub>L</sub> 49 Gene Vary with Respect to the Defect in the U <sub>L</sub> 41 Gene Encoding Host Shutoff RNase
Journal of Virology·2007· 47 citedOpen Access
Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA
Proceedings of the National Academy of Sciences·2007· 73 citedOpen Access
The Virion Host Shutoff Protein (U <sub>L</sub> 41) of Herpes Simplex Virus 1 Is an Endoribonuclease with a Substrate Specificity Similar to That of RNase A
Journal of Virology·2006· 99 citedOpen Access
The U <sub>L</sub> 41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins
Proceedings of the National Academy of Sciences·2006· 86 citedOpen Access
The U <sub>L</sub> 41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs
Proceedings of the National Academy of Sciences·2004· 76 citedOpen Access
Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells
Biochemical Society Transactions·2004· 28 cited
Cells Lacking NF-κB or in Which NF-κB Is Not Activated Vary with Respect to Ability To Sustain Herpes Simplex Virus 1 Replication and Are Not Susceptible to Apoptosis Induced by a Replication-Incompetent Mutant Virus
Journal of Virology·2004· 41 citedOpen Access
Herpes Simplex Virus 1 Induces Cytoplasmic Accumulation of TIA-1/TIAR and both Synthesis and Cytoplasmic Accumulation of Tristetraprolin, Two Cellular Proteins That Bind and Destabilize AU-Rich RNAs
Journal of Virology·2004· 84 citedOpen Access
The herpes simplex virus 1 <i> U <sub>L</sub> 41 </i> gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific
Proceedings of the National Academy of Sciences·2004· 95 citedOpen Access
Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis
Proceedings of the National Academy of Sciences·2003· 75 citedOpen Access
The Stress-Inducible Immediate-Early Responsive Gene IEX-1 Is Activated in Cells Infected with Herpes Simplex Virus 1, but Several Viral Mechanisms, Including 3′ Degradation of Its RNA, Preclude Expression of the Gene
Journal of Virology·2003· 47 citedOpen Access
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Frequent Co-authors

Bernard Roizman(23), Weiran Zhang(9), Audrey Esclatine(6), P. Verani(6), Maria Teresa Sciortino(5), Maurizio Federico(5), Antonio Mastino(3), Minfeng Shu(3), Francesca Carlini(3), Giovanni Battista Rossi(3), John Varga(2), Stefano Fiore(2), Brian J. Nickoloff(2), Kimberly E. Foreman(2), William A. Haseltine(2), Chris M. Farnet(2), Fausto Titti(2), Stefano Buttò(2), Filomena Nappi(2), Snežna Sodin‐Šemrl(1)