Sonal Rajyaguru

Medicine · Health Sciences

21h-index1.6kcitations37works0.02yr avg
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Research Topics

Hepatitis C virus research(27), HIV/AIDS drug development and treatment(25), Hepatitis B Virus Studies(12), Biochemical and Molecular Research(9), Monoclonal and Polyclonal Antibodies Research(3)

Publications37 total

CCDC 671179: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
<i>In vitro</i> Selection of Resistance to Sofosbuvir in HCV Replicons of Genotype-1 to -6
Antiviral Therapy·2016· 39 cited
Discovery of <i>N</i>-[4-[6-<i>tert</i>-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1<i>H</i>-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase
Journal of Medicinal Chemistry·2013· 30 citedOpen Access
Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B
Journal of Medicinal Chemistry·2013· 36 citedOpen Access
Development and characterization of a replicon-based phenotypic assay for assessing HCV NS4B from clinical isolates
Antiviral Research·2013· 2 cited
1175 IN-VITRO FITNESS AND RESISTANCE ANALYSES OF NS3 MUTANTS DETECTED BY POPULATION AND DEEP SEQUENCING IN HCV PATIENTS FROM PHASE I STUDIES OF GS-9451 AND GS-9256
Journal of Hepatology·2012· 3 cited
1196 NOVEL, POTENT, PAN-GENOTYPIC HCV NS3/4A PROTEASE INHIBITORS WITH A HIGH BARRIER TO RESISTANCE
Journal of Hepatology·2011Open Access
Cyclic amide bioisosterism: Strategic application to the design and synthesis of HCV NS5B polymerase inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 28 citedOpen Access
Modulation of alpha interferon anti-hepatitis C virus activity by ISG15
Journal of General Virology·2009· 41 cited
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: Structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides
Bioorganic & Medicinal Chemistry Letters·2009· 35 citedOpen Access
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: Synthesis and optimization studies of benzothiazine-substituted tetramic acids
Bioorganic & Medicinal Chemistry Letters·2009· 15 citedOpen Access
The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)
Bioorganic & Medicinal Chemistry Letters·2009· 60 cited
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure–activity relationships of benzothiazine-substituted quinolinediones
Bioorganic & Medicinal Chemistry Letters·2009· 35 cited
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 31 cited
Silibinin (Legalon-SIL) Inhibits HCV Replication In Vitro
Antiviral Research·2009
2′-Deoxy-nucleoside Analogs can be Potent Dual Inhibitors of HCV and HIV Replication with Selectivity against Human Polymerases
Antiviral Research·2009
The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine
Journal of Medicinal Chemistry·2009· 91 cited
960 SUPPRESSION OF IN VITRO RESISTANCE DEVELOPMENT AFTER TREATMENT OF THE HCV REPLICON WITH NS3/4A INHIBITOR ITMN-191 (R7227) IN COMBINATION WITH NUCLEOSIDE INHIBITOR R7128 OR R1626
Journal of Hepatology·2009· 5 citedOpen Access
952 2′ -DEOXY-NUCLEOSIDE ANALOGS AS POTENT DUAL INHIBITORS OF HCV AND HIV REPLICATION, WITH SELECTIVITY AGAINST OTHER VIRAL AND HUMAN POLYMERASES
Journal of Hepatology·2009
959 SUBTYPE SPECIFIC RESISTANCE PROFILES AFTER SELECTION OF HCV GENOTYPE 1A OR GENOTYPE 1B REPLICONS WITH TELAPREVIR OR HCV-796
Journal of Hepatology·2009
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Frequent Co-authors

Isabel Nájera(28), Vincent Lévêque(21), Sophie Le Pogam(20), Klaus Klumpp(15), Nick Cammack(12), David B. Smith(9), Seth F. Harris(8), Joseph A. Martin(7), Matthew F. McCown(6), Julian Symons(6), Julie Q. Hang(6), Genadiy Kalayanov(6), Nils Gunnar Johansson(6), R. Hendricks(6), Wen-Rong Jiang(5), N. Cammack(5), Han Ma(5), Simran Kular(5), Stacey R. Spencer(5), James F. Blake(5)