Brian T. Chait

Northwestern University — PH

Chemistry · Physical Sciences

127h-index73.1kcitations752works1.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Mass Spectrometry Techniques and Applications(144), Immunotherapy and Immune Responses(130), vaccines and immunoinformatics approaches(124), Viral-associated cancers and disorders(90), Advanced Proteomics Techniques and Applications(82)

Publications752 total

Division of labor in trypanosome RNA processing and export through expanded Mex67 paralogs
Nucleic Acids Research·2025Open Access
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
Nature Cell Biology·2025· 1 citedOpen Access
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
Non-hematotoxic Tim-3/CD70 dual-targeting CAR T cells promote potent anti-leukemia activity against acute myeloid leukemia
Blood·2025Open Access
Distinct quaternary states, intermediates, and autoinhibition during loading of the DnaB-replicative helicase by the phage λP helicase loader
Nucleic Acids Research·2025Open Access
A Nature-Inspired Ion Trap for Parallel Manipulation of Ions on a Massive Scale
2025Open Access
DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA
Nucleic Acids Research·2025· 4 citedOpen Access
Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin
Structure·2025· 3 cited
Abstract 2830 Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex
Journal of Biological Chemistry·2025Open Access
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery
2025· 9 cited
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with CTP
EMPIAR dataset·2025Open Access
Cryo-EM of SARS-SoV-2 pre-incorporation replication-transcription complex with GTP
EMPIAR dataset·2025Open Access
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with UTP
EMPIAR dataset·2025Open Access
Cryo-EM of SARS-CoV-2 pre-incorporation replication-transcription complex with ATP
EMPIAR dataset·2025Open Access
Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex
Molecular Cell·2025· 8 cited
Cryo-EM of RNAP post-terminal complexes bound to RapA+ADP+AlF3 on negatively supercoiled DNA
EMPIAR dataset·2025Open Access
Cryo-EM of RNAP post-terminal complexes on negatively supercoiled DNA
EMPIAR dataset·2025Open Access
Cryo-EM of SARS-CoV-2 nsp13-replication-transcription complex (nsp13-RTC) (no detergent)
EMPIAR dataset·2025Open Access
Cryo-EM of SARS-CoV-2 nsp13-replication-transcription complex (nsp13-RTC)
EMPIAR dataset·2025Open Access
Unique mechanisms to increase structural stability and enhance antigen binding in nanobodies
Structure·2025· 12 citedOpen Access
page 1 of 38Next →

Frequent Co-authors

Roderick MacKinnon(7), Michael P. Rout(6), Wenzhu Zhang(6), Steven L. Cohen(5), Alice Lee(4), Martine Cadène(4), Ronald C. Beavis(4), Rosemary Williams(4), Andrej Săli(4), Andrew N. Krutchinsky(4), Viswanatham Katta(4), Youxing Jiang(3), Jiayun Chen(3), John D. Aitchison(3), Adisetyantari Suprapto(3), Michel C. Nussenzweig(3), Alan J. Tackett(3), C. David Allis(3), Frank Alber(3), Svetlana Dokudovskaya(3)