Carl‐Henrik Heldin

Uppsala University — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

144h-index76.2kcitations650works2.12yr avg
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Research Topics

TGF-β signaling in diseases(179), Cell Adhesion Molecules Research(76), Protein Kinase Regulation and GTPase Signaling(57), Platelet Disorders and Treatments(51), PI3K/AKT/mTOR signaling in cancer(47)

Publications649 total

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
Cell Death and Differentiation·2025· 2 citedOpen Access
Special issue: frontiers in recent advances on cancer diagnosis and treatment
Upsala Journal of Medical Sciences·2024Open Access
PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells
Growth Factors·2024Open Access
376 (PB364): Targeting TGF-β signaling components to ameliorate Palbociclib resistance in breast cancer
European Journal of Cancer·2024
ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
Cell Communication and Signaling·2024· 4 citedOpen Access
Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
Journal of Biological Chemistry·2024· 9 citedOpen Access
Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma
2024Open Access
Abstract A155: The TGF-β/BMP signaling cascades induce opposing fates in breast cancer and medulloblastoma through chromatin and cell cycle modulation
Molecular Cancer Therapeutics·2023
The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
Cell Communication and Signaling·2023· 11 citedOpen Access
SelectiveTGFb-inhib
EU Research·2023
SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
BMC Molecular and Cell Biology·2023· 3 citedOpen Access
The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
International Journal of Molecular Sciences·2023· 4 citedOpen Access
Supplementary Table 1 and Fig 1-8 including legends from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Data from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Antibodies from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Primer sequences from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Endothelial cell qPCR array from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Endothelial cell qPCR array from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Primer sequences from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
Supplementary Table 1 and Fig 1-8 including legends from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
2023Open Access
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Frequent Co-authors

Bengt Westermark(11), Peter ten Dijke(11), Aristidis Moustakas(10), Kohei Miyazono(9), Arne Östman(6), Christer Wernstedt(6), Kristian Pietras(5), Åke Wasteson(5), Ulf Hellman(5), Kristofer Rubin(4), Hidetoshi Yamashita(4), Susumu Itoh(3), Lena Claesson‐Welsh(3), Ann Johnsson(3), Serhiy Souchelnytskyi(3), Christer Betsholtz(3), Maréne Landström(3), Jung San Huang(2), Thomas F. Deuel(2), T. Kuber Sampath(2)