Louis J. Lombardo

Bristol-Myers Squibb (United States) — United States

Medicine · Health Sciences

31h-index5.1kcitations102works0.02yr avg
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Research Topics

Chronic Myeloid Leukemia Treatments(12), Cytokine Signaling Pathways and Interactions(11), Angiogenesis and VEGF in Cancer(10), Asymmetric Synthesis and Catalysis(8), Myeloproliferative Neoplasms: Diagnosis and Treatment(8)

Publications102 total

ASSESSMENT OF STAND CHARACTERISTICS AND SOIL OF UPPER PARANA ATLANTIC FORESTS (PARAGUAY) REVEALS HIGH HABITAT HETEROGENEITY
JOURNAL OF TROPICAL FOREST SCIENCE·2023· 2 citedOpen Access
Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations
Bioorganic & Medicinal Chemistry Letters·2023· 1 citedOpen Access
Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor
Journal of Medicinal Chemistry·2021· 6 cited
Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2
Journal of Medicinal Chemistry·2020· 76 citedOpen Access
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
Journal of Medicinal Chemistry·2019· 345 citedOpen Access
Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)
Journal of Medicinal Chemistry·2019· 84 citedOpen Access
Identification of Imidazo[1,2-<i>b</i>]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors
ACS Medicinal Chemistry Letters·2019· 49 citedOpen Access
Identification of potent tricyclic prodrug S1P<sub>1</sub> receptor modulators
MedChemComm·2016· 6 citedOpen Access
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms
ACS Medicinal Chemistry Letters·2015· 39 citedOpen Access
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-<i>d</i>]pyrrolo[2,3-<i>b</i>]pyridine Inhibitors
ACS Medicinal Chemistry Letters·2015· 15 citedOpen Access
9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2015· 11 citedOpen Access
Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors
ACS Medicinal Chemistry Letters·2015· 88 citedOpen Access
Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain
Journal of Medicinal Chemistry·2013· 38 citedOpen Access
Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain
Journal of Medicinal Chemistry·2013· 28 citedOpen Access
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 34 citedOpen Access
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists
Bioorganic & Medicinal Chemistry Letters·2012· 23 citedOpen Access
Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2
Leukemia·2011· 77 cited
Abstract DDT01-03: Discovery of BMS-911543, a highly selective JAK2 inhibitor, as a clinical candidate for the treatment of myeloproliferative disease and other malignancies
Cancer Research·2011
Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3
Bioorganic & Medicinal Chemistry Letters·2011· 16 citedOpen Access
Characterization of BMS-911543, a Functionally Selective Small Molecule Inhibitor of JAK2
Blood·2010· 4 cited
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Frequent Co-authors

R. M. Borzilleri(18), John S. Tokarski(16), John T. Hunt(15), Zhen‐Wei Cai(11), Joseph Fargnoli(11), Amrita V. Kamath(10), Barri Wautlet(10), Donna Wei(10), Rajeev S. Bhide(10), Celia D’Arienzo(9), Robert Jeyaseelan(9), Joel C. Barrish(7), Punit Marathe(7), Robert J. Schmidt(7), George L. Trainor(7), David Williams(7), Ligang Qian(7), Francis Y. Lee(6), Dianlin Xie(6), Gretchen M. Schroeder(6)