Bingchuan Wei

Synthetic Genomics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index850citations41works5.12yr avg
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Research Topics

Protein purification and stability(15), Microfluidic and Capillary Electrophoresis Applications(12), Analytical Chemistry and Chromatography(12), Monoclonal and Polyclonal Antibodies Research(8), RNA and protein synthesis mechanisms(7)

Publications41 total

Real-Time Bioconjugation Reaction Monitoring of Antibody–Drug Conjugates with Multiattribute High-Throughput Hydrophobic Interaction Chromatography
Analytical Chemistry·2025
Enzymatic assay based platform for the chiral purity assessment of cathepsin-cleavable antibody-drug conjugate linker-drugs
Analytica Chimica Acta·2025
A versatile two-dimensional liquid chromatography coupled to high-resolution mass spectrometry platform for unraveling chromatographic profiles of large synthetic oligonucleotides
Analytica Chimica Acta·2025
Real-Time Monitoring of Higher-Order Structure of RNAs by Temperature-Course Size Exclusion Chromatography and Microfluidic Modulation Spectroscopy
Analytical Chemistry·2025· 5 cited
Revealing New Analytical Insights into RNA Complexes: Divalent siRNA Characterization by Liquid Chromatography and Mass Spectrometry
Analytical Chemistry·2025· 7 cited
Online native hydrophobic interaction chromatography-mass spectrometry of antibody-drug conjugates
mAbs·2024· 7 citedOpen Access
Applications of hydrophilic interaction and mixed-mode liquid chromatography in pharmaceutical analysis
Journal of Chromatography A·2024· 13 cited
Probing the higher order structure of oligonucleotides through anion exchange chromatography
Journal of Chromatography A·2024· 9 cited
Probing the Protein–Excipient Interaction in the Orally Delivered Protein by Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry and Molecular Dynamics
Analytical Chemistry·2023· 4 cited
Predicting Long-Term Stability of an Oral Delivered Antibody Drug Product with Accelerated Stability Assessment Program Modeling
Molecular Pharmaceutics·2023· 6 cited
Characterization of synthetic guide ribonucleic acids through hydrophilic interaction chromatography coupled with mass spectrometry
Journal of Chromatography A·2023· 13 cited
Characterization of Synthetic Guide Ribonucleic Acids Through Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry
SSRN Electronic Journal·2023Open Access
Analysis of therapeutic nucleic acids by capillary electrophoresis
Journal of Pharmaceutical and Biomedical Analysis·2022· 44 cited
Development of an ion pairing reversed-phase liquid chromatography-mass spectrometry method for characterization of clustered regularly interspaced short palindromic repeats guide ribonucleic acid
Journal of Chromatography A·2022· 36 cited
Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics
mAbs·2021· 30 citedOpen Access
Protein‐induced conformational change in glycans decreases the resolution of glycoproteins in hydrophilic interaction liquid chromatography
Journal of Separation Science·2021· 2 citedOpen Access
Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation
mAbs·2021· 57 citedOpen Access
An Approach to Bioactivity Assessment for Critical Quality Attribute Identification Based on Antibody-Antigen Complex Structure
Journal of Pharmaceutical Sciences·2020· 5 citedOpen Access
Development of a rapid reversed-phase liquid chromatographic method for total free thiol quantitation in protein therapeutics
Journal of Pharmaceutical and Biomedical Analysis·2020· 5 cited
Predictive <i>In Vitro</i> Vitreous and Serum Models and Methods to Assess Thiol-Related Quality Attributes in Protein Therapeutics
Analytical Chemistry·2020· 6 cited
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Frequent Co-authors

Kelly Zhang(12), Mary J. Wirth(10), Lance Cadang(8), Lulu Dai(5), Benjamin J. Rogers(4), Wendy Sandoval(4), Alexandre Goyon(4), Jenny Wang(4), Bifan Chen(4), Jenny Wang(4), Yonghua Taylor Zhang(3), Wilson Phung(3), Guanghui Han(3), Douglas S. Malkin(3), Feng Yang(3), Mengxia Zhao(3), Daniel T. Chiu(3), Xuan Gao(2), Saeed Izadi(2), Hui‐Min Zhang(2)